Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response

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Cancer cells, which use more glucose than normal cells and accumulate extracellular lactate even under normoxic conditions (Warburg effect), have been reported to undergo cell death under glucose deprivation, whereas normal cells remain viable. As it may be relevant to exploit the molecular mechanis...

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Detalles Bibliográficos
Autores principales: Palorini, R, Cammarata, F, Balestrieri, C, Monestiroli, A, Vasso, M, Gelfi, C, Alberghina, L, Chiaradonna, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730427/
https://www.ncbi.nlm.nih.gov/pubmed/23868065
http://dx.doi.org/10.1038/cddis.2013.257
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