HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma

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Heat-shock protein (HSP) 70 is aberrantly expressed in different malignancies and has a cancer-specific cell-protective effect. As such, it has emerged as a promising target for anticancer therapy. In this study, the effect of the HSP70-specific inhibitor (PES), also Pifitrin-μ, on primary effusion...

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Detalles Bibliográficos
Autores principales: Granato, M, Lacconi, V, Peddis, M, Lotti, L V, Renzo, L D, Gonnella, R, Santarelli, R, Trivedi, P, Frati, L, D'Orazi, G, Faggioni, A, Cirone, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730433/
https://www.ncbi.nlm.nih.gov/pubmed/23868063
http://dx.doi.org/10.1038/cddis.2013.263
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