Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice

ABT-263 and its structural analogues ABT-199 and ABT-737 inhibit B-cell lymphoma 2 (Bcl-2), BCL2L1 long isoform (Bcl-xL) and BCL2L2 (Bcl-w) proteins and promote cancer cell death. Here, we show that at non-cytotoxic concentrations, these small molecules accelerate the deaths of non-cancerous cells i...

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Detalles Bibliográficos
Autores principales: Kakkola, L, Denisova, O V, Tynell, J, Viiliäinen, J, Ysenbaert, T, Matos, R C, Nagaraj, A, Öhman, T, Kuivanen, S, Paavilainen, H, Feng, L, Yadav, B, Julkunen, I, Vapalahti, O, Hukkanen, V, Stenman, J, Aittokallio, T, Verschuren, E W, Ojala, P M, Nyman, T, Saelens, X, Dzeyk, K, Kainov, D E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730437/
https://www.ncbi.nlm.nih.gov/pubmed/23887633
http://dx.doi.org/10.1038/cddis.2013.267

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