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Progressive atrophy of retinal pigment epithelium after trypan-blue-assisted ILM peeling for macular hole surgery

We report a case of progressive atrophy of the retinal pigment epithelium (RPE) after trypan-blue-assisted peeling of internal limiting membrane (ILM) for macular hole surgery. A 68-year-old Caucasian female underwent a 20-g pars plana vitrectomy for a chronic stage-3 macular hole. The ILM was stain...

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Autores principales: Jain, Sachin, Kishore, Kamal, Sharma, Yog Raj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730510/
https://www.ncbi.nlm.nih.gov/pubmed/23619488
http://dx.doi.org/10.4103/0301-4738.111180
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author Jain, Sachin
Kishore, Kamal
Sharma, Yog Raj
author_facet Jain, Sachin
Kishore, Kamal
Sharma, Yog Raj
author_sort Jain, Sachin
collection PubMed
description We report a case of progressive atrophy of the retinal pigment epithelium (RPE) after trypan-blue-assisted peeling of internal limiting membrane (ILM) for macular hole surgery. A 68-year-old Caucasian female underwent a 20-g pars plana vitrectomy for a chronic stage-3 macular hole. The ILM was stained with 0.06% trypan blue (VisionBlue™, DORC Netherlands) for 2 min after fluid air exchange. Dye was reapplied for another 2 min due to poor staining. The ILM was completely removed around the macular hole with forceps. RPE atrophy was noticed at the edge of the hole 1 month after surgery. It progressively increased in intensity and enlarged over 2 years. Her final visual acuity was counting fingers, significantly worse compared to her presenting visual acuity of 20/200. Progressive atrophy of RPE in our patient was most likely due to the toxicity of trypan blue. Reapplication of the dye may increase the likelihood of toxicity.
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spelling pubmed-37305102013-08-06 Progressive atrophy of retinal pigment epithelium after trypan-blue-assisted ILM peeling for macular hole surgery Jain, Sachin Kishore, Kamal Sharma, Yog Raj Indian J Ophthalmol Brief Communication We report a case of progressive atrophy of the retinal pigment epithelium (RPE) after trypan-blue-assisted peeling of internal limiting membrane (ILM) for macular hole surgery. A 68-year-old Caucasian female underwent a 20-g pars plana vitrectomy for a chronic stage-3 macular hole. The ILM was stained with 0.06% trypan blue (VisionBlue™, DORC Netherlands) for 2 min after fluid air exchange. Dye was reapplied for another 2 min due to poor staining. The ILM was completely removed around the macular hole with forceps. RPE atrophy was noticed at the edge of the hole 1 month after surgery. It progressively increased in intensity and enlarged over 2 years. Her final visual acuity was counting fingers, significantly worse compared to her presenting visual acuity of 20/200. Progressive atrophy of RPE in our patient was most likely due to the toxicity of trypan blue. Reapplication of the dye may increase the likelihood of toxicity. Medknow Publications & Media Pvt Ltd 2013-05 /pmc/articles/PMC3730510/ /pubmed/23619488 http://dx.doi.org/10.4103/0301-4738.111180 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Jain, Sachin
Kishore, Kamal
Sharma, Yog Raj
Progressive atrophy of retinal pigment epithelium after trypan-blue-assisted ILM peeling for macular hole surgery
title Progressive atrophy of retinal pigment epithelium after trypan-blue-assisted ILM peeling for macular hole surgery
title_full Progressive atrophy of retinal pigment epithelium after trypan-blue-assisted ILM peeling for macular hole surgery
title_fullStr Progressive atrophy of retinal pigment epithelium after trypan-blue-assisted ILM peeling for macular hole surgery
title_full_unstemmed Progressive atrophy of retinal pigment epithelium after trypan-blue-assisted ILM peeling for macular hole surgery
title_short Progressive atrophy of retinal pigment epithelium after trypan-blue-assisted ILM peeling for macular hole surgery
title_sort progressive atrophy of retinal pigment epithelium after trypan-blue-assisted ilm peeling for macular hole surgery
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730510/
https://www.ncbi.nlm.nih.gov/pubmed/23619488
http://dx.doi.org/10.4103/0301-4738.111180
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