O-GlcNAcylation-Inducing Treatments Inhibit Estrogen Receptor α Expression and Confer Resistance to 4-OH-Tamoxifen in Human Breast Cancer-Derived MCF-7 Cells

O-GlcNAcylation (addition of N-acetyl-glucosamine on serine or threonine residues) is a post-translational modification that regulates stability, activity or localization of cytosolic and nuclear proteins. O-linked N-acetylgluocosmaine transferase (OGT) uses UDP-GlcNAc, produced in the hexosamine bi...

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Detalles Bibliográficos
Autores principales: Kanwal, Shahzina, Fardini, Yann, Pagesy, Patrick, N’Tumba-Byn, Thierry, Pierre-Eugène, Cécile, Masson, Elodie, Hampe, Cornelia, Issad, Tarik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730543/
https://www.ncbi.nlm.nih.gov/pubmed/23935944
http://dx.doi.org/10.1371/journal.pone.0069150

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