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The role of pattern recognition receptors in intestinal inflammation
Recognition of microorganisms by pattern-recognition receptors (PRRs) is the primary component of innate immunity that is responsible for the maintenance of host–microbial interactions in intestinal mucosa. Dysregulation in host–commensal interactions has been implicated as the central pathogenesis...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730813/ https://www.ncbi.nlm.nih.gov/pubmed/23515136 http://dx.doi.org/10.1038/mi.2013.13 |
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author | Fukata, M Arditi, M |
author_facet | Fukata, M Arditi, M |
author_sort | Fukata, M |
collection | PubMed |
description | Recognition of microorganisms by pattern-recognition receptors (PRRs) is the primary component of innate immunity that is responsible for the maintenance of host–microbial interactions in intestinal mucosa. Dysregulation in host–commensal interactions has been implicated as the central pathogenesis of inflammatory bowel disease (IBD), which predisposes to developing colorectal cancer. Recent animal studies have begun to outline some unique physiology and pathology involving each PRR signaling in the intestine. The major roles played by PRRs in the gut appear to be the regulation of the number and the composition of commensal bacteria, epithelial proliferation, and mucosal permeability in response to epithelial injury. In addition, PRR signaling in lamina propria immune cells may be involved in induction of inflammation in response to invasion of pathogens. Because some PRR-deficient mice have shown variable susceptibility to colitis, the outcome of intestinal inflammation may be modified depending on PRR signaling in epithelial cells, immune cells, and the composition of commensal flora. Through recent findings in animal models of IBD, this review will discuss how abnormal PRR signaling may contribute to the pathogenesis of inflammation and inflammation-associated tumorigenesis in the intestine. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/mi.2013.13) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-3730813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-37308132013-11-01 The role of pattern recognition receptors in intestinal inflammation Fukata, M Arditi, M Mucosal Immunol Article Recognition of microorganisms by pattern-recognition receptors (PRRs) is the primary component of innate immunity that is responsible for the maintenance of host–microbial interactions in intestinal mucosa. Dysregulation in host–commensal interactions has been implicated as the central pathogenesis of inflammatory bowel disease (IBD), which predisposes to developing colorectal cancer. Recent animal studies have begun to outline some unique physiology and pathology involving each PRR signaling in the intestine. The major roles played by PRRs in the gut appear to be the regulation of the number and the composition of commensal bacteria, epithelial proliferation, and mucosal permeability in response to epithelial injury. In addition, PRR signaling in lamina propria immune cells may be involved in induction of inflammation in response to invasion of pathogens. Because some PRR-deficient mice have shown variable susceptibility to colitis, the outcome of intestinal inflammation may be modified depending on PRR signaling in epithelial cells, immune cells, and the composition of commensal flora. Through recent findings in animal models of IBD, this review will discuss how abnormal PRR signaling may contribute to the pathogenesis of inflammation and inflammation-associated tumorigenesis in the intestine. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/mi.2013.13) contains supplementary material, which is available to authorized users. Nature Publishing Group US 2013-03-20 2013 /pmc/articles/PMC3730813/ /pubmed/23515136 http://dx.doi.org/10.1038/mi.2013.13 Text en © Society for Mucosal Immunology 2013 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Fukata, M Arditi, M The role of pattern recognition receptors in intestinal inflammation |
title | The role of pattern recognition receptors in intestinal inflammation |
title_full | The role of pattern recognition receptors in intestinal inflammation |
title_fullStr | The role of pattern recognition receptors in intestinal inflammation |
title_full_unstemmed | The role of pattern recognition receptors in intestinal inflammation |
title_short | The role of pattern recognition receptors in intestinal inflammation |
title_sort | role of pattern recognition receptors in intestinal inflammation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730813/ https://www.ncbi.nlm.nih.gov/pubmed/23515136 http://dx.doi.org/10.1038/mi.2013.13 |
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