Full Design Automation of Multi-State RNA Devices to Program Gene Expression Using Energy-Based Optimization

Small RNAs (sRNAs) can operate as regulatory agents to control protein expression by interaction with the 5′ untranslated region of the mRNA. We have developed a physicochemical framework, relying on base pair interaction energies, to design multi-state sRNA devices by solving an optimization proble...

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Detalles Bibliográficos
Autores principales: Rodrigo, Guillermo, Landrain, Thomas E., Majer, Eszter, Daròs, José-Antonio, Jaramillo, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731219/
https://www.ncbi.nlm.nih.gov/pubmed/23935479
http://dx.doi.org/10.1371/journal.pcbi.1003172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731219/
https://www.ncbi.nlm.nih.gov/pubmed/23935479
http://dx.doi.org/10.1371/journal.pcbi.1003172

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