Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques

Dengue virus is transmitted by Aedes mosquitoes and infects at least 100 million people every year. Progressive urbanization in Asia and South-Central America and the geographic expansion of Aedes mosquito habitats have accelerated the global spread of dengue, resulting in a continuously increasing...

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Detalles Bibliográficos
Autores principales: Züst, Roland, Dong, Hongping, Li, Xiao-Feng, Chang, David C., Zhang, Bo, Balakrishnan, Thavamalar, Toh, Ying-Xiu, Jiang, Tao, Li, Shi-Hua, Deng, Yong-Qiang, Ellis, Brett R., Ellis, Esther M., Poidinger, Michael, Zolezzi, Francesca, Qin, Cheng-Feng, Shi, Pei-Yong, Fink, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731252/
https://www.ncbi.nlm.nih.gov/pubmed/23935499
http://dx.doi.org/10.1371/journal.ppat.1003521

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