Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

The presence of the Philadelphia chromosome in patients with acute lymphoblastic leukemia (Ph(+)ALL) is a negative prognostic indicator. Tyrosine kinase inhibitors (TKI) that target BCR/ABL, such as imatinib, have improved treatment of Ph(+)ALL and are generally incorporated into induction regimens....

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Detalles Bibliográficos
Autores principales: Irwin, Mary E., Nelson, Laura D., Santiago-O’Farrill, Janice M., Knouse, Phillip D., Miller, Claudia P., Palla, Shana L., Siwak, Doris R., Mills, Gordon B., Estrov, Zeev, Li, Shulin, Kornblau, Steven M., Hughes, Dennis P., Chandra, Joya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731286/
https://www.ncbi.nlm.nih.gov/pubmed/23936456
http://dx.doi.org/10.1371/journal.pone.0070608

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