Trichothecin Induces Cell Death in NF-κB Constitutively Activated Human Cancer Cells via Inhibition of IKKβ Phosphorylation

Constitutive activation of the transcription factor nuclear factor-κB (NF-κB) is involved in tumorigenesis and chemo-resistance. As the key regulator of NF-κB, IKKβ is a major therapeutic target for various cancers. Trichothecin (TCN) is a metabolite isolated from an endophytic fungus of the herbal...

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Detalles Bibliográficos
Autores principales: Su, Jia, Zhao, Peiji, Kong, Lingmei, Li, Xingyao, Yan, Juming, Zeng, Ying, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731298/
https://www.ncbi.nlm.nih.gov/pubmed/23936501
http://dx.doi.org/10.1371/journal.pone.0071333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731298/
https://www.ncbi.nlm.nih.gov/pubmed/23936501
http://dx.doi.org/10.1371/journal.pone.0071333

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