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Isoniazid Inhibits the Heme-Based Reactivity of Mycobacterium tuberculosis Truncated Hemoglobin N

Isoniazid represents a first-line anti-tuberculosis medication in prevention and treatment. This prodrug is activated by a mycobacterial catalase-peroxidase enzyme called KatG in Mycobacterium tuberculosis), thereby inhibiting the synthesis of mycolic acid, required for the mycobacterial cell wall....

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Detalles Bibliográficos
Autores principales:	Ascenzi, Paolo, Coletta, Andrea, Cao, Yu, Trezza, Viviana, Leboffe, Loris, Fanali, Gabriella, Fasano, Mauro, Pesce, Alessandra, Ciaccio, Chiara, Marini, Stefano, Coletta, Massimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731299/ https://www.ncbi.nlm.nih.gov/pubmed/23936350 http://dx.doi.org/10.1371/journal.pone.0069762

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