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A Strategy to Model Nonmonotonic Dose-Response Curve and Estimate IC(50)
The half-maximal inhibitory concentration IC[Image: see text] is an important pharmacodynamic index of drug effectiveness. To estimate this value, the dose response relationship needs to be established, which is generally achieved by fitting monotonic sigmoidal models. However, recent studies on Hum...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731310/ https://www.ncbi.nlm.nih.gov/pubmed/23936323 http://dx.doi.org/10.1371/journal.pone.0069301 |