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Network Effects of Risk Behavior Change Following Prophylactic Interventions
We formulated a network-based model to understand how risk behavior change in conjunction with failure of prophylactic interventions can lead to unintended outcomes where “less (intervention) is more (effective).” Our model captures the distinction between one- and two-sided risk behavior change. In...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731323/ https://www.ncbi.nlm.nih.gov/pubmed/23936290 http://dx.doi.org/10.1371/journal.pone.0064653 |
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author | Rajaraman, Rajmohan Sun, Zhifeng Sundaram, Ravi Vullikanti, Anil Kumar S. |
author_facet | Rajaraman, Rajmohan Sun, Zhifeng Sundaram, Ravi Vullikanti, Anil Kumar S. |
author_sort | Rajaraman, Rajmohan |
collection | PubMed |
description | We formulated a network-based model to understand how risk behavior change in conjunction with failure of prophylactic interventions can lead to unintended outcomes where “less (intervention) is more (effective).” Our model captures the distinction between one- and two-sided risk behavior change. In one-sided situations (e.g. influenza/H1N1) it is sufficient for either individual in an interaction to exhibit risk behavior change whereas in two-sided situations (e.g. AIDS/HIV) it is necessary for both individuals in the interaction to exhibit risk behavior change, for a potential transmission of the disease. A central discovery is that this phenomenon occurs at differing levels of intervention coverage depending upon the “sidedness” of the interaction. We find that for one-sided interactions, sufficiently high vaccination coverage is necessary for mitigating the effects of risk behavior; for two-sided interactions, it is essential to combine prophylactic treatments with programs aimed at reducing risky behavior. Furthermore, again dependent on the “sidedness,” targeting highly connected nodes can be strictly worse than uniformly random interventions at the same level of coverage. |
format | Online Article Text |
id | pubmed-3731323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37313232013-08-09 Network Effects of Risk Behavior Change Following Prophylactic Interventions Rajaraman, Rajmohan Sun, Zhifeng Sundaram, Ravi Vullikanti, Anil Kumar S. PLoS One Research Article We formulated a network-based model to understand how risk behavior change in conjunction with failure of prophylactic interventions can lead to unintended outcomes where “less (intervention) is more (effective).” Our model captures the distinction between one- and two-sided risk behavior change. In one-sided situations (e.g. influenza/H1N1) it is sufficient for either individual in an interaction to exhibit risk behavior change whereas in two-sided situations (e.g. AIDS/HIV) it is necessary for both individuals in the interaction to exhibit risk behavior change, for a potential transmission of the disease. A central discovery is that this phenomenon occurs at differing levels of intervention coverage depending upon the “sidedness” of the interaction. We find that for one-sided interactions, sufficiently high vaccination coverage is necessary for mitigating the effects of risk behavior; for two-sided interactions, it is essential to combine prophylactic treatments with programs aimed at reducing risky behavior. Furthermore, again dependent on the “sidedness,” targeting highly connected nodes can be strictly worse than uniformly random interventions at the same level of coverage. Public Library of Science 2013-08-01 /pmc/articles/PMC3731323/ /pubmed/23936290 http://dx.doi.org/10.1371/journal.pone.0064653 Text en © 2013 Rajaraman et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Rajaraman, Rajmohan Sun, Zhifeng Sundaram, Ravi Vullikanti, Anil Kumar S. Network Effects of Risk Behavior Change Following Prophylactic Interventions |
title | Network Effects of Risk Behavior Change Following Prophylactic Interventions |
title_full | Network Effects of Risk Behavior Change Following Prophylactic Interventions |
title_fullStr | Network Effects of Risk Behavior Change Following Prophylactic Interventions |
title_full_unstemmed | Network Effects of Risk Behavior Change Following Prophylactic Interventions |
title_short | Network Effects of Risk Behavior Change Following Prophylactic Interventions |
title_sort | network effects of risk behavior change following prophylactic interventions |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731323/ https://www.ncbi.nlm.nih.gov/pubmed/23936290 http://dx.doi.org/10.1371/journal.pone.0064653 |
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