Behavioral Characterization of A53T Mice Reveals Early and Late Stage Deficits Related to Parkinson’s Disease

Parkinson's disease (PD) pathology is characterized by the formation of intra-neuronal inclusions called Lewy bodies, which are comprised of alpha-synuclein (α-syn). Duplication, triplication or genetic mutations in α-syn (A53T, A30P and E46K) are linked to autosomal dominant PD; thus implicati...

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Detalles Bibliográficos
Autores principales: Paumier, Katrina L., Sukoff Rizzo, Stacey J., Berger, Zdenek, Chen, Yi, Gonzales, Cathleen, Kaftan, Edward, Li, Li, Lotarski, Susan, Monaghan, Michael, Shen, Wei, Stolyar, Polina, Vasilyev, Dmytro, Zaleska, Margaret, D. Hirst, Warren, Dunlop, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731353/
https://www.ncbi.nlm.nih.gov/pubmed/23936403
http://dx.doi.org/10.1371/journal.pone.0070274

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