Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release

AIM: To determine if cytokine release with a solid phase assay is predictive of adverse responses for a range of therapeutic mAbs. METHODS: Cytokine ELISAs and a multi-array system were used to compare responses generated by different therapeutic mAbs using a solid phase assay. Flow cytometry was em...

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Detalles Bibliográficos
Autores principales: Eastwood, David, Bird, Chris, Dilger, Paula, Hockley, Jason, Findlay, Lucy, Poole, Stephen, Thorpe, Susan J, Wadhwa, Meenu, Thorpe, Robin, Stebbings, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2013
Materias:
Drug Safety
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731604/
https://www.ncbi.nlm.nih.gov/pubmed/23701319
http://dx.doi.org/10.1111/bcp.12165

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