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Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling

The RAF kinase family is essential in mediating signal transduction from RAS to ERK. BRAF constitutively active mutations correlate with human cancer development. However, the precise molecular regulation of BRAF activation is not fully understood. Here we report that BRAF is modified by Lys63-linke...

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Detalles Bibliográficos
Autores principales:	An, Lei, Jia, Wei, Yu, Yang, Zou, Ning, Liang, Li, Zhao, Yanling, Fan, Yihui, Cheng, Jin, Shi, Zhongcheng, Xu, Gufeng, Li, Grace, Yang, Jianhua, Zhang, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731650/ https://www.ncbi.nlm.nih.gov/pubmed/23907581 http://dx.doi.org/10.1038/srep02344

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