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‘From Death, Lead Me to Immortality’ – Mantra of Ageing Skeletal Muscle
Skeletal muscle is a post-mitotic tissue maintained by repair and regeneration through a population of stem cell-like satellite cells. Following muscle injury, satellite cell proliferation is mediated by local signals ensuring sufficient progeny for tissue repair. Age–related changes in satellite ce...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731816/ https://www.ncbi.nlm.nih.gov/pubmed/24294106 http://dx.doi.org/10.2174/1389202911314040004 |
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author | Saini, Amarjit Mastana, Sarabjit Myers, Fiona Lewis, Mark Peter |
author_facet | Saini, Amarjit Mastana, Sarabjit Myers, Fiona Lewis, Mark Peter |
author_sort | Saini, Amarjit |
collection | PubMed |
description | Skeletal muscle is a post-mitotic tissue maintained by repair and regeneration through a population of stem cell-like satellite cells. Following muscle injury, satellite cell proliferation is mediated by local signals ensuring sufficient progeny for tissue repair. Age–related changes in satellite cells as well as to the local and systemic environment potentially impact on the capacity of satellite cells to generate sufficient progeny in an ageing organism resulting in diminished regeneration. ‘Rejuvenation’ of satellite cell progeny and regenerative capacity by environmental stimuli effectors suggest that a subset of age-dependent satellite cell changes may be reversible. Epigenetic regulation of satellite stem cells that include DNA methylation and histone modifications which regulate gene expression are potential mechanisms for such reversible changes and have been shown to control organismal longevity. The area of health and ageing that is likely to benefit soonest from advances in the biology of adult stem cells is the emerging field of regenerative medicine. Further studies are needed to elucidate the mechanisms by which epigenetic modifications regulate satellite stem cell function and will require an increased understanding of stem-cell biology, the environment of the aged tissue and the interaction between the two. |
format | Online Article Text |
id | pubmed-3731816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-37318162013-12-01 ‘From Death, Lead Me to Immortality’ – Mantra of Ageing Skeletal Muscle Saini, Amarjit Mastana, Sarabjit Myers, Fiona Lewis, Mark Peter Curr Genomics Article Skeletal muscle is a post-mitotic tissue maintained by repair and regeneration through a population of stem cell-like satellite cells. Following muscle injury, satellite cell proliferation is mediated by local signals ensuring sufficient progeny for tissue repair. Age–related changes in satellite cells as well as to the local and systemic environment potentially impact on the capacity of satellite cells to generate sufficient progeny in an ageing organism resulting in diminished regeneration. ‘Rejuvenation’ of satellite cell progeny and regenerative capacity by environmental stimuli effectors suggest that a subset of age-dependent satellite cell changes may be reversible. Epigenetic regulation of satellite stem cells that include DNA methylation and histone modifications which regulate gene expression are potential mechanisms for such reversible changes and have been shown to control organismal longevity. The area of health and ageing that is likely to benefit soonest from advances in the biology of adult stem cells is the emerging field of regenerative medicine. Further studies are needed to elucidate the mechanisms by which epigenetic modifications regulate satellite stem cell function and will require an increased understanding of stem-cell biology, the environment of the aged tissue and the interaction between the two. Bentham Science Publishers 2013-06 2013-06 /pmc/articles/PMC3731816/ /pubmed/24294106 http://dx.doi.org/10.2174/1389202911314040004 Text en © 2013 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Saini, Amarjit Mastana, Sarabjit Myers, Fiona Lewis, Mark Peter ‘From Death, Lead Me to Immortality’ – Mantra of Ageing Skeletal Muscle |
title | ‘From Death, Lead Me to Immortality’ – Mantra of Ageing Skeletal
Muscle
|
title_full | ‘From Death, Lead Me to Immortality’ – Mantra of Ageing Skeletal
Muscle
|
title_fullStr | ‘From Death, Lead Me to Immortality’ – Mantra of Ageing Skeletal
Muscle
|
title_full_unstemmed | ‘From Death, Lead Me to Immortality’ – Mantra of Ageing Skeletal
Muscle
|
title_short | ‘From Death, Lead Me to Immortality’ – Mantra of Ageing Skeletal
Muscle
|
title_sort | ‘from death, lead me to immortality’ – mantra of ageing skeletal
muscle |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731816/ https://www.ncbi.nlm.nih.gov/pubmed/24294106 http://dx.doi.org/10.2174/1389202911314040004 |
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