Targeted Myostatin Gene Editing in Multiple Mammalian Species Directed by a Single Pair of TALE Nucleases

Myostatin (MSTN) is a negative regulator of skeletal muscle mass. Strategies to block myostatin signaling pathway have been extensively pursued to increase muscle mass in various disease settings including muscular dystrophy. Here, we report a new class of reagents based on transcription activator-l...

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Detalles Bibliográficos
Autores principales: Xu, Li, Zhao, Piming, Mariano, Andrew, Han, Renzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731890/
https://www.ncbi.nlm.nih.gov/pubmed/23900226
http://dx.doi.org/10.1038/mtna.2013.39

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