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HIV and innate immunity – a genomics perspective

Innate immunity is a theme of increasing interest for HIV research. However, the term is overstretched to cover biological barriers, cellular systems, soluble factors, signaling pathways, and effectors and is inconsistently applied. A clearer semantic classification of the components of innate immun...

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Detalles Bibliográficos
Autores principales: Rausell, Antonio, McLaren, Paul J., Telenti, Amalio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732074/
https://www.ncbi.nlm.nih.gov/pubmed/23967380
http://dx.doi.org/10.12703/P5-29
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author Rausell, Antonio
McLaren, Paul J.
Telenti, Amalio
author_facet Rausell, Antonio
McLaren, Paul J.
Telenti, Amalio
author_sort Rausell, Antonio
collection PubMed
description Innate immunity is a theme of increasing interest for HIV research. However, the term is overstretched to cover biological barriers, cellular systems, soluble factors, signaling pathways, and effectors and is inconsistently applied. A clearer semantic classification of the components of innate immunity is needed, which will have direct relevance to the interpretation of human genome variation. Here, we discuss genomic approaches that can assist in re-defining the perimeter of innate immunity. We place particular emphasis on the characteristics of effectors of the intracellular defense against HIV and other pathogens.
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spelling pubmed-37320742013-08-21 HIV and innate immunity – a genomics perspective Rausell, Antonio McLaren, Paul J. Telenti, Amalio F1000Prime Rep Review Article Innate immunity is a theme of increasing interest for HIV research. However, the term is overstretched to cover biological barriers, cellular systems, soluble factors, signaling pathways, and effectors and is inconsistently applied. A clearer semantic classification of the components of innate immunity is needed, which will have direct relevance to the interpretation of human genome variation. Here, we discuss genomic approaches that can assist in re-defining the perimeter of innate immunity. We place particular emphasis on the characteristics of effectors of the intracellular defense against HIV and other pathogens. Faculty of 1000 Ltd 2013-08-01 /pmc/articles/PMC3732074/ /pubmed/23967380 http://dx.doi.org/10.12703/P5-29 Text en © 2013 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Rausell, Antonio
McLaren, Paul J.
Telenti, Amalio
HIV and innate immunity – a genomics perspective
title HIV and innate immunity – a genomics perspective
title_full HIV and innate immunity – a genomics perspective
title_fullStr HIV and innate immunity – a genomics perspective
title_full_unstemmed HIV and innate immunity – a genomics perspective
title_short HIV and innate immunity – a genomics perspective
title_sort hiv and innate immunity – a genomics perspective
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732074/
https://www.ncbi.nlm.nih.gov/pubmed/23967380
http://dx.doi.org/10.12703/P5-29
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