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Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription

Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhan...

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Detalles Bibliográficos
Autores principales: Stees, Jared S., Varn, Fred, Huang, Suming, Strouboulis, John, Bungert, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732451/
https://www.ncbi.nlm.nih.gov/pubmed/23919179
http://dx.doi.org/10.3390/biology1030778
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author Stees, Jared S.
Varn, Fred
Huang, Suming
Strouboulis, John
Bungert, Jörg
author_facet Stees, Jared S.
Varn, Fred
Huang, Suming
Strouboulis, John
Bungert, Jörg
author_sort Stees, Jared S.
collection PubMed
description Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation.
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spelling pubmed-37324512013-08-03 Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription Stees, Jared S. Varn, Fred Huang, Suming Strouboulis, John Bungert, Jörg Biology (Basel) Review Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation. MDPI 2012-12-05 /pmc/articles/PMC3732451/ /pubmed/23919179 http://dx.doi.org/10.3390/biology1030778 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Stees, Jared S.
Varn, Fred
Huang, Suming
Strouboulis, John
Bungert, Jörg
Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription
title Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription
title_full Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription
title_fullStr Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription
title_full_unstemmed Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription
title_short Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription
title_sort recruitment of transcription complexes to enhancers and the role of enhancer transcription
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732451/
https://www.ncbi.nlm.nih.gov/pubmed/23919179
http://dx.doi.org/10.3390/biology1030778
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