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Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription
Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhan...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732451/ https://www.ncbi.nlm.nih.gov/pubmed/23919179 http://dx.doi.org/10.3390/biology1030778 |
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author | Stees, Jared S. Varn, Fred Huang, Suming Strouboulis, John Bungert, Jörg |
author_facet | Stees, Jared S. Varn, Fred Huang, Suming Strouboulis, John Bungert, Jörg |
author_sort | Stees, Jared S. |
collection | PubMed |
description | Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation. |
format | Online Article Text |
id | pubmed-3732451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37324512013-08-03 Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription Stees, Jared S. Varn, Fred Huang, Suming Strouboulis, John Bungert, Jörg Biology (Basel) Review Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation. MDPI 2012-12-05 /pmc/articles/PMC3732451/ /pubmed/23919179 http://dx.doi.org/10.3390/biology1030778 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Stees, Jared S. Varn, Fred Huang, Suming Strouboulis, John Bungert, Jörg Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription |
title | Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription |
title_full | Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription |
title_fullStr | Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription |
title_full_unstemmed | Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription |
title_short | Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription |
title_sort | recruitment of transcription complexes to enhancers and the role of enhancer transcription |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732451/ https://www.ncbi.nlm.nih.gov/pubmed/23919179 http://dx.doi.org/10.3390/biology1030778 |
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