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Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents

Stryphnodendron adstringens has a high tannin content and is used as an antiseptic and antimicrobial and in the treatment of leucorrhea, gonorrhea, wound healing, and gastritis. The present study evaluated the toxic effects of the heptamer prodelphinidin (F2) from the stem bark of S. adstringens in...

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Autores principales: Costa, Marco Antonio, Palazzo de Mello, João Carlos, Kaneshima, Edílson Nobuyoshi, Ueda-Nakamura, Tânia, Dias Filho, Benedito Prado, Audi, Elisabeth Aparecida, Nakamura, Celso Vataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732597/
https://www.ncbi.nlm.nih.gov/pubmed/23970938
http://dx.doi.org/10.1155/2013/841580
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author Costa, Marco Antonio
Palazzo de Mello, João Carlos
Kaneshima, Edílson Nobuyoshi
Ueda-Nakamura, Tânia
Dias Filho, Benedito Prado
Audi, Elisabeth Aparecida
Nakamura, Celso Vataru
author_facet Costa, Marco Antonio
Palazzo de Mello, João Carlos
Kaneshima, Edílson Nobuyoshi
Ueda-Nakamura, Tânia
Dias Filho, Benedito Prado
Audi, Elisabeth Aparecida
Nakamura, Celso Vataru
author_sort Costa, Marco Antonio
collection PubMed
description Stryphnodendron adstringens has a high tannin content and is used as an antiseptic and antimicrobial and in the treatment of leucorrhea, gonorrhea, wound healing, and gastritis. The present study evaluated the toxic effects of the heptamer prodelphinidin (F2) from the stem bark of S. adstringens in rodents. In the acute toxicity test, the mice that received oral doses exhibited reversible effects, with an LD(50) of 3.015 mg · kg(−1). In the chronic toxicity test at 90 days, Wistar rats were treated with different doses of F2 (10, 100, and 200 mg · kg(−1)). In the biochemical, hematological, and histopathological examinations and open-field test, the different dose groups did not exhibit significant differences compared with controls. The present results indicate that F2 from the stem bark of S. adstringens caused no toxicity with acute and chronic oral treatment in rodents at the doses administered.
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spelling pubmed-37325972013-08-22 Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents Costa, Marco Antonio Palazzo de Mello, João Carlos Kaneshima, Edílson Nobuyoshi Ueda-Nakamura, Tânia Dias Filho, Benedito Prado Audi, Elisabeth Aparecida Nakamura, Celso Vataru Evid Based Complement Alternat Med Research Article Stryphnodendron adstringens has a high tannin content and is used as an antiseptic and antimicrobial and in the treatment of leucorrhea, gonorrhea, wound healing, and gastritis. The present study evaluated the toxic effects of the heptamer prodelphinidin (F2) from the stem bark of S. adstringens in rodents. In the acute toxicity test, the mice that received oral doses exhibited reversible effects, with an LD(50) of 3.015 mg · kg(−1). In the chronic toxicity test at 90 days, Wistar rats were treated with different doses of F2 (10, 100, and 200 mg · kg(−1)). In the biochemical, hematological, and histopathological examinations and open-field test, the different dose groups did not exhibit significant differences compared with controls. The present results indicate that F2 from the stem bark of S. adstringens caused no toxicity with acute and chronic oral treatment in rodents at the doses administered. Hindawi Publishing Corporation 2013 2013-07-18 /pmc/articles/PMC3732597/ /pubmed/23970938 http://dx.doi.org/10.1155/2013/841580 Text en Copyright © 2013 Marco Antonio Costa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Costa, Marco Antonio
Palazzo de Mello, João Carlos
Kaneshima, Edílson Nobuyoshi
Ueda-Nakamura, Tânia
Dias Filho, Benedito Prado
Audi, Elisabeth Aparecida
Nakamura, Celso Vataru
Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents
title Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents
title_full Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents
title_fullStr Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents
title_full_unstemmed Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents
title_short Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents
title_sort acute and chronic toxicity of an aqueous fraction of the stem bark of stryphnodendron adstringens (barbatimão) in rodents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732597/
https://www.ncbi.nlm.nih.gov/pubmed/23970938
http://dx.doi.org/10.1155/2013/841580
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