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Raised Activity of L-Type Calcium Channels Renders Neurons Prone to Form Paroxysmal Depolarization Shifts

Neuronal L-type voltage-gated calcium channels (LTCCs) are involved in several physiological functions, but increased activity of LTCCs has been linked to pathology. Due to the coupling of LTCC-mediated Ca(2+) influx to Ca(2+)-dependent conductances, such as K(Ca) or non-specific cation channels, LT...

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Detalles Bibliográficos
Autores principales: Rubi, Lena, Schandl, Ulla, Lagler, Michael, Geier, Petra, Spies, Daniel, Gupta, Kuheli Das, Boehm, Stefan, Kubista, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732764/
https://www.ncbi.nlm.nih.gov/pubmed/23695859
http://dx.doi.org/10.1007/s12017-013-8234-1