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HIV and Neurocognitive Dysfunction
The spectrum of HIV-associated neurocognitive disorder (HAND) has been dramatically altered in the setting of widely available effective antiretroviral therapy (ART). Once culminating in dementia in many individuals infected with HIV, HAND now typically manifests as more subtle, though still morbid,...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer US
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732773/ https://www.ncbi.nlm.nih.gov/pubmed/23860944 http://dx.doi.org/10.1007/s11904-013-0171-y |
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author | Spudich, Serena |
author_facet | Spudich, Serena |
author_sort | Spudich, Serena |
collection | PubMed |
description | The spectrum of HIV-associated neurocognitive disorder (HAND) has been dramatically altered in the setting of widely available effective antiretroviral therapy (ART). Once culminating in dementia in many individuals infected with HIV, HAND now typically manifests as more subtle, though still morbid, forms of cognitive impairment in persons surviving long-term with treated HIV infection. Despite the substantial improvement in severity of this disorder, the fact that neurologic injury persists despite ART remains a challenge to the community of patients, providers and investigators aiming to optimize quality of life for those living with HIV. Cognitive dysfunction in treated HIV may reflect early irreversible CNS injury accrued before ART is typically initiated, ongoing low-level CNS infection and progressive injury in the setting of ART, or comborbidities including effects of treatment which may confound the beneficial reduction in viral replication and immune activation effected by ART. |
format | Online Article Text |
id | pubmed-3732773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-37327732013-08-05 HIV and Neurocognitive Dysfunction Spudich, Serena Curr HIV/AIDS Rep Metabolic Complications and Comorbidity (JM Kilby, Section Editor) The spectrum of HIV-associated neurocognitive disorder (HAND) has been dramatically altered in the setting of widely available effective antiretroviral therapy (ART). Once culminating in dementia in many individuals infected with HIV, HAND now typically manifests as more subtle, though still morbid, forms of cognitive impairment in persons surviving long-term with treated HIV infection. Despite the substantial improvement in severity of this disorder, the fact that neurologic injury persists despite ART remains a challenge to the community of patients, providers and investigators aiming to optimize quality of life for those living with HIV. Cognitive dysfunction in treated HIV may reflect early irreversible CNS injury accrued before ART is typically initiated, ongoing low-level CNS infection and progressive injury in the setting of ART, or comborbidities including effects of treatment which may confound the beneficial reduction in viral replication and immune activation effected by ART. Springer US 2013-07-17 2013 /pmc/articles/PMC3732773/ /pubmed/23860944 http://dx.doi.org/10.1007/s11904-013-0171-y Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Metabolic Complications and Comorbidity (JM Kilby, Section Editor) Spudich, Serena HIV and Neurocognitive Dysfunction |
title | HIV and Neurocognitive Dysfunction |
title_full | HIV and Neurocognitive Dysfunction |
title_fullStr | HIV and Neurocognitive Dysfunction |
title_full_unstemmed | HIV and Neurocognitive Dysfunction |
title_short | HIV and Neurocognitive Dysfunction |
title_sort | hiv and neurocognitive dysfunction |
topic | Metabolic Complications and Comorbidity (JM Kilby, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732773/ https://www.ncbi.nlm.nih.gov/pubmed/23860944 http://dx.doi.org/10.1007/s11904-013-0171-y |
work_keys_str_mv | AT spudichserena hivandneurocognitivedysfunction |