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5′ Unlocked Nucleic Acid Modification Improves siRNA Targeting

Optimization of small interfering RNAs (siRNAs) is important in RNA interference (RNAi)-based therapeutic development. Some specific chemical modifications can control which siRNA strand is selected by the RNA-induced silencing complex (RISC) for gene silencing. Intended strand selection will increa...

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Detalles Bibliográficos
Autores principales:	Snead, Nicholas M, Escamilla-Powers, Julie R, Rossi, John J, McCaffrey, Anton P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732871/ https://www.ncbi.nlm.nih.gov/pubmed/23820891 http://dx.doi.org/10.1038/mtna.2013.36

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