An insight into genetics of non-syndromic cleft palate

Our proband is a 29-year-old man, who is affected with soft cleft palate and hypernasality. A study of about six generations of this family pedigree shows that cleft palate has repeatedly occurred in males, with probably a X-linked recessive pattern of inheritance. Interestingly, the sister of the p...

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Detalles Bibliográficos
Autores principales: Nouri, Nayereh, Karimi, Padideh, Mansoor, Salehi, Memarzadeh, Mehrdad, Ganji, Hamid, Sedghi, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732890/
https://www.ncbi.nlm.nih.gov/pubmed/23930251
http://dx.doi.org/10.4103/2277-9175.107969
Descripción
Sumario:Our proband is a 29-year-old man, who is affected with soft cleft palate and hypernasality. A study of about six generations of this family pedigree shows that cleft palate has repeatedly occurred in males, with probably a X-linked recessive pattern of inheritance. Interestingly, the sister of the proband is affected with hypernasality and she has an affected son. This is the first report of X-linked inheritance pattern of cleft palate in Iran.

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