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5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT

Recent studies have shown that endogenous serotonin is not required for colonic peristalsis in vitro, nor gastrointestinal (GI) transit in vivo. However, antagonists of 5-Hydroxytryptamine (5-HT) receptors can inhibit peristalsis and GI-transit in mammals, including humans. This raises the question...

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Detalles Bibliográficos
Autores principales:	Sia, Tiong C., Whiting, Malcolm, Kyloh, Melinda, Nicholas, Sarah J., Oliver, John, Brookes, Simon J., Dinning, Phil G., Wattchow, David A., Spencer, Nick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732893/ https://www.ncbi.nlm.nih.gov/pubmed/23935564 http://dx.doi.org/10.3389/fnins.2013.00136

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