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The relation between Vitamin D status with fatigue and depressive symptoms of multiple sclerosis

BACKGROUND: The relation between Vitamin D deficiency with depressive and fatigue symptoms in both Multiple sclerosis (MS) patients and healthy population have been reported. To represent our regional achievement in this field we investigated the relation between Vitamin D status with fatigue and de...

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Autores principales: Ashtari, Fereshteh, Ajalli, Masoomeh, Shaygannejad, Vahid, Akbari, Mojtaba, Hovsepian, Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732898/
https://www.ncbi.nlm.nih.gov/pubmed/23930114
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author Ashtari, Fereshteh
Ajalli, Masoomeh
Shaygannejad, Vahid
Akbari, Mojtaba
Hovsepian, Silva
author_facet Ashtari, Fereshteh
Ajalli, Masoomeh
Shaygannejad, Vahid
Akbari, Mojtaba
Hovsepian, Silva
author_sort Ashtari, Fereshteh
collection PubMed
description BACKGROUND: The relation between Vitamin D deficiency with depressive and fatigue symptoms in both Multiple sclerosis (MS) patients and healthy population have been reported. To represent our regional achievement in this field we investigated the relation between Vitamin D status with fatigue and depressive symptoms in MS patients. MATERIALS AND METHODS: In two hundred MS patients, depressive symptoms and fatigue were measured using Beck PC (BDI-PC) and FFS scale, respectively. Venous blood sample was obtained from all participants and serum 25-hydroxy Vitamin D was measured by radioimmunoassay (RIA) method. Mean score of FSS, BDI-PC and EDSS were compared in patients with normal and low level of Vitamin D. The relation between FSS, BDI-PC score, EDSS and low Vitamin D status was determined. RESULTS: There was a moderate significant correlation between MS disability evaluated by EDSS and fatigue (r = 0.37, P < 0.001) and depression (r = 0.26, P < 0.001). The prevalence of low Vitamin D status was 48.5%. Low Vitamin D status was inversely associated with depressive symptoms of patients with MS (P = 0.02 rs = -0.16), but there was not significant correlation between Vitamin D and fatigue symptoms (P = 0.2). CONCLUSION: More interventional studies for determining the role of Vitamin D supplements in this regard is recommended.
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spelling pubmed-37328982013-08-08 The relation between Vitamin D status with fatigue and depressive symptoms of multiple sclerosis Ashtari, Fereshteh Ajalli, Masoomeh Shaygannejad, Vahid Akbari, Mojtaba Hovsepian, Silva J Res Med Sci Original Article BACKGROUND: The relation between Vitamin D deficiency with depressive and fatigue symptoms in both Multiple sclerosis (MS) patients and healthy population have been reported. To represent our regional achievement in this field we investigated the relation between Vitamin D status with fatigue and depressive symptoms in MS patients. MATERIALS AND METHODS: In two hundred MS patients, depressive symptoms and fatigue were measured using Beck PC (BDI-PC) and FFS scale, respectively. Venous blood sample was obtained from all participants and serum 25-hydroxy Vitamin D was measured by radioimmunoassay (RIA) method. Mean score of FSS, BDI-PC and EDSS were compared in patients with normal and low level of Vitamin D. The relation between FSS, BDI-PC score, EDSS and low Vitamin D status was determined. RESULTS: There was a moderate significant correlation between MS disability evaluated by EDSS and fatigue (r = 0.37, P < 0.001) and depression (r = 0.26, P < 0.001). The prevalence of low Vitamin D status was 48.5%. Low Vitamin D status was inversely associated with depressive symptoms of patients with MS (P = 0.02 rs = -0.16), but there was not significant correlation between Vitamin D and fatigue symptoms (P = 0.2). CONCLUSION: More interventional studies for determining the role of Vitamin D supplements in this regard is recommended. Medknow Publications & Media Pvt Ltd 2013-03 /pmc/articles/PMC3732898/ /pubmed/23930114 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ashtari, Fereshteh
Ajalli, Masoomeh
Shaygannejad, Vahid
Akbari, Mojtaba
Hovsepian, Silva
The relation between Vitamin D status with fatigue and depressive symptoms of multiple sclerosis
title The relation between Vitamin D status with fatigue and depressive symptoms of multiple sclerosis
title_full The relation between Vitamin D status with fatigue and depressive symptoms of multiple sclerosis
title_fullStr The relation between Vitamin D status with fatigue and depressive symptoms of multiple sclerosis
title_full_unstemmed The relation between Vitamin D status with fatigue and depressive symptoms of multiple sclerosis
title_short The relation between Vitamin D status with fatigue and depressive symptoms of multiple sclerosis
title_sort relation between vitamin d status with fatigue and depressive symptoms of multiple sclerosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732898/
https://www.ncbi.nlm.nih.gov/pubmed/23930114
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