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Urotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions

BACKGROUND: Contrast induced kidney injury is an acute renal dysfunction that is secondary to the administration of radio contrast media. The purpose of this study was to evaluate the levels of urotensin-II (UT-II) and endothelin-I (ET-I) after contrast media administration in patients undergoing pe...

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Autores principales: Ulas, Turgay, Buyukhatipoglu, Hakan, Dal, Mehmet S., Kirhan, Idris, Kaya, Zekeriya, Demir, Mehmet E., Tursun, Irfan, Eren, Mehmet A., Aydogan, Timucin, Sezen, Yusuf, Aksoy, Nurten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732900/
https://www.ncbi.nlm.nih.gov/pubmed/23930116
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author Ulas, Turgay
Buyukhatipoglu, Hakan
Dal, Mehmet S.
Kirhan, Idris
Kaya, Zekeriya
Demir, Mehmet E.
Tursun, Irfan
Eren, Mehmet A.
Aydogan, Timucin
Sezen, Yusuf
Aksoy, Nurten
author_facet Ulas, Turgay
Buyukhatipoglu, Hakan
Dal, Mehmet S.
Kirhan, Idris
Kaya, Zekeriya
Demir, Mehmet E.
Tursun, Irfan
Eren, Mehmet A.
Aydogan, Timucin
Sezen, Yusuf
Aksoy, Nurten
author_sort Ulas, Turgay
collection PubMed
description BACKGROUND: Contrast induced kidney injury is an acute renal dysfunction that is secondary to the administration of radio contrast media. The purpose of this study was to evaluate the levels of urotensin-II (UT-II) and endothelin-I (ET-I) after contrast media administration in patients undergoing percutaneous coronary interventions. MATERIALS AND METHODS: In this prospective cohort study, we evaluated 78 patients with coronary artery disease who were scheduled for and ultimately underwent percutaneous coronary interventions. As a contrast material, nonionic contrast media was used in various amounts (70-480 mL). Blood and urine samples were obtained to measure U-II, ET-I just before and at the twenty-fourth hour of percutaneous coronary interventions. RESULTS: Compared to baseline, twenty-fourth hour creatinine levels were significantly increased (P < 0.001). The twenty-fourth hour serum and urine levels of both UT-II and ET-I were also significantly increased compared to baseline (P < 0.001 for all) and 24(th) hour serum and urine UT-II (r = 0.322, P = 0.004; r = 0.302, P = 0.007 respectively), ET-I (r = 0.511, P < 0.001; r = 0.266, P = 0.019 respectively) levels were significantly correlated with the amount of contrast media. CONCLUSION: Our study indicates that; increased UT-II and ET-I levels seem to be a consequence of hazardous effects of contrast media on blood vessels and the kidney.
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spelling pubmed-37329002013-08-08 Urotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions Ulas, Turgay Buyukhatipoglu, Hakan Dal, Mehmet S. Kirhan, Idris Kaya, Zekeriya Demir, Mehmet E. Tursun, Irfan Eren, Mehmet A. Aydogan, Timucin Sezen, Yusuf Aksoy, Nurten J Res Med Sci Original Article BACKGROUND: Contrast induced kidney injury is an acute renal dysfunction that is secondary to the administration of radio contrast media. The purpose of this study was to evaluate the levels of urotensin-II (UT-II) and endothelin-I (ET-I) after contrast media administration in patients undergoing percutaneous coronary interventions. MATERIALS AND METHODS: In this prospective cohort study, we evaluated 78 patients with coronary artery disease who were scheduled for and ultimately underwent percutaneous coronary interventions. As a contrast material, nonionic contrast media was used in various amounts (70-480 mL). Blood and urine samples were obtained to measure U-II, ET-I just before and at the twenty-fourth hour of percutaneous coronary interventions. RESULTS: Compared to baseline, twenty-fourth hour creatinine levels were significantly increased (P < 0.001). The twenty-fourth hour serum and urine levels of both UT-II and ET-I were also significantly increased compared to baseline (P < 0.001 for all) and 24(th) hour serum and urine UT-II (r = 0.322, P = 0.004; r = 0.302, P = 0.007 respectively), ET-I (r = 0.511, P < 0.001; r = 0.266, P = 0.019 respectively) levels were significantly correlated with the amount of contrast media. CONCLUSION: Our study indicates that; increased UT-II and ET-I levels seem to be a consequence of hazardous effects of contrast media on blood vessels and the kidney. Medknow Publications & Media Pvt Ltd 2013-03 /pmc/articles/PMC3732900/ /pubmed/23930116 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ulas, Turgay
Buyukhatipoglu, Hakan
Dal, Mehmet S.
Kirhan, Idris
Kaya, Zekeriya
Demir, Mehmet E.
Tursun, Irfan
Eren, Mehmet A.
Aydogan, Timucin
Sezen, Yusuf
Aksoy, Nurten
Urotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions
title Urotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions
title_full Urotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions
title_fullStr Urotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions
title_full_unstemmed Urotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions
title_short Urotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions
title_sort urotensin-ii and endothelin-i levels after contrast media administration in patients undergoing percutaneous coronary interventions
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732900/
https://www.ncbi.nlm.nih.gov/pubmed/23930116
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