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Serum cryoglobulins and disease activity in systematic lupus erythematosus
BACKGROUND: To determine the prevalence of cryoglobulins in Iranian patients with systemic lupus erythematosus (SLE) and evaluate the correlation of cryoglobulins with disease activity in these patients. MATERIALS AND METHODS: In a cross-sectional study, we investigated 80 consecutive women who fulf...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732906/ https://www.ncbi.nlm.nih.gov/pubmed/23930122 |
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author | Karimifar, Mansoor Pourajam, Samaneh Tahmasebi, Afshin Mottaghi, Peyman |
author_facet | Karimifar, Mansoor Pourajam, Samaneh Tahmasebi, Afshin Mottaghi, Peyman |
author_sort | Karimifar, Mansoor |
collection | PubMed |
description | BACKGROUND: To determine the prevalence of cryoglobulins in Iranian patients with systemic lupus erythematosus (SLE) and evaluate the correlation of cryoglobulins with disease activity in these patients. MATERIALS AND METHODS: In a cross-sectional study, we investigated 80 consecutive women who fulfilled the 1982 revised criteria of the American College of Rheumatology for the classification of SLE. All the patients had undergone a medical interview and general physical examination by a rheumatologist for clinical and serologic characteristics of SLE. For the determination of cryoglobulins, sera were collected by a standard protocol at 37°C, and after incubation at 4°C for seven days, the level of cryoglobulins was estimated for each patient. RESULTS: Cryoglobulins were detected in the sera of 39 (48.8%) patients. All of these patients had cryocrit over 5%. Disease was active in 30 patients [SLEDAI ≥6 (DAI: disease activity index)] and inactive in 50 (SLEDAI <6). There was no significant difference between active and inactive patients for the presence of serum cryoglobulins (r = 0.086, P = 0.56). A significant positive correlation was observed between antinuclear antibody (ANA), anti-dsDNA (dsDNA: Double-stranded deoxyribonucleic acid), CH50 (CH50: total hemolytic complement assay), and C-reactive protein (CRP) (r = 0.21, P = 0.004, r = 0.65, P = 0.001, r = 0.45, P = 0.023, r = 0.38, P = 0.036, respectively). Hepatitis C virus (HCV) infection was not detected in any of the SLE patients. CONCLUSION: Although the presence of cryoglobulins in the SLE patients correlated with positive anti-ds DNA and low CH50, it could not be predict activity of the disease. |
format | Online Article Text |
id | pubmed-3732906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37329062013-08-08 Serum cryoglobulins and disease activity in systematic lupus erythematosus Karimifar, Mansoor Pourajam, Samaneh Tahmasebi, Afshin Mottaghi, Peyman J Res Med Sci Original Article BACKGROUND: To determine the prevalence of cryoglobulins in Iranian patients with systemic lupus erythematosus (SLE) and evaluate the correlation of cryoglobulins with disease activity in these patients. MATERIALS AND METHODS: In a cross-sectional study, we investigated 80 consecutive women who fulfilled the 1982 revised criteria of the American College of Rheumatology for the classification of SLE. All the patients had undergone a medical interview and general physical examination by a rheumatologist for clinical and serologic characteristics of SLE. For the determination of cryoglobulins, sera were collected by a standard protocol at 37°C, and after incubation at 4°C for seven days, the level of cryoglobulins was estimated for each patient. RESULTS: Cryoglobulins were detected in the sera of 39 (48.8%) patients. All of these patients had cryocrit over 5%. Disease was active in 30 patients [SLEDAI ≥6 (DAI: disease activity index)] and inactive in 50 (SLEDAI <6). There was no significant difference between active and inactive patients for the presence of serum cryoglobulins (r = 0.086, P = 0.56). A significant positive correlation was observed between antinuclear antibody (ANA), anti-dsDNA (dsDNA: Double-stranded deoxyribonucleic acid), CH50 (CH50: total hemolytic complement assay), and C-reactive protein (CRP) (r = 0.21, P = 0.004, r = 0.65, P = 0.001, r = 0.45, P = 0.023, r = 0.38, P = 0.036, respectively). Hepatitis C virus (HCV) infection was not detected in any of the SLE patients. CONCLUSION: Although the presence of cryoglobulins in the SLE patients correlated with positive anti-ds DNA and low CH50, it could not be predict activity of the disease. Medknow Publications & Media Pvt Ltd 2013-03 /pmc/articles/PMC3732906/ /pubmed/23930122 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Karimifar, Mansoor Pourajam, Samaneh Tahmasebi, Afshin Mottaghi, Peyman Serum cryoglobulins and disease activity in systematic lupus erythematosus |
title | Serum cryoglobulins and disease activity in systematic lupus erythematosus |
title_full | Serum cryoglobulins and disease activity in systematic lupus erythematosus |
title_fullStr | Serum cryoglobulins and disease activity in systematic lupus erythematosus |
title_full_unstemmed | Serum cryoglobulins and disease activity in systematic lupus erythematosus |
title_short | Serum cryoglobulins and disease activity in systematic lupus erythematosus |
title_sort | serum cryoglobulins and disease activity in systematic lupus erythematosus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732906/ https://www.ncbi.nlm.nih.gov/pubmed/23930122 |
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