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Serum cryoglobulins and disease activity in systematic lupus erythematosus

BACKGROUND: To determine the prevalence of cryoglobulins in Iranian patients with systemic lupus erythematosus (SLE) and evaluate the correlation of cryoglobulins with disease activity in these patients. MATERIALS AND METHODS: In a cross-sectional study, we investigated 80 consecutive women who fulf...

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Autores principales: Karimifar, Mansoor, Pourajam, Samaneh, Tahmasebi, Afshin, Mottaghi, Peyman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732906/
https://www.ncbi.nlm.nih.gov/pubmed/23930122
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author Karimifar, Mansoor
Pourajam, Samaneh
Tahmasebi, Afshin
Mottaghi, Peyman
author_facet Karimifar, Mansoor
Pourajam, Samaneh
Tahmasebi, Afshin
Mottaghi, Peyman
author_sort Karimifar, Mansoor
collection PubMed
description BACKGROUND: To determine the prevalence of cryoglobulins in Iranian patients with systemic lupus erythematosus (SLE) and evaluate the correlation of cryoglobulins with disease activity in these patients. MATERIALS AND METHODS: In a cross-sectional study, we investigated 80 consecutive women who fulfilled the 1982 revised criteria of the American College of Rheumatology for the classification of SLE. All the patients had undergone a medical interview and general physical examination by a rheumatologist for clinical and serologic characteristics of SLE. For the determination of cryoglobulins, sera were collected by a standard protocol at 37°C, and after incubation at 4°C for seven days, the level of cryoglobulins was estimated for each patient. RESULTS: Cryoglobulins were detected in the sera of 39 (48.8%) patients. All of these patients had cryocrit over 5%. Disease was active in 30 patients [SLEDAI ≥6 (DAI: disease activity index)] and inactive in 50 (SLEDAI <6). There was no significant difference between active and inactive patients for the presence of serum cryoglobulins (r = 0.086, P = 0.56). A significant positive correlation was observed between antinuclear antibody (ANA), anti-dsDNA (dsDNA: Double-stranded deoxyribonucleic acid), CH50 (CH50: total hemolytic complement assay), and C-reactive protein (CRP) (r = 0.21, P = 0.004, r = 0.65, P = 0.001, r = 0.45, P = 0.023, r = 0.38, P = 0.036, respectively). Hepatitis C virus (HCV) infection was not detected in any of the SLE patients. CONCLUSION: Although the presence of cryoglobulins in the SLE patients correlated with positive anti-ds DNA and low CH50, it could not be predict activity of the disease.
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spelling pubmed-37329062013-08-08 Serum cryoglobulins and disease activity in systematic lupus erythematosus Karimifar, Mansoor Pourajam, Samaneh Tahmasebi, Afshin Mottaghi, Peyman J Res Med Sci Original Article BACKGROUND: To determine the prevalence of cryoglobulins in Iranian patients with systemic lupus erythematosus (SLE) and evaluate the correlation of cryoglobulins with disease activity in these patients. MATERIALS AND METHODS: In a cross-sectional study, we investigated 80 consecutive women who fulfilled the 1982 revised criteria of the American College of Rheumatology for the classification of SLE. All the patients had undergone a medical interview and general physical examination by a rheumatologist for clinical and serologic characteristics of SLE. For the determination of cryoglobulins, sera were collected by a standard protocol at 37°C, and after incubation at 4°C for seven days, the level of cryoglobulins was estimated for each patient. RESULTS: Cryoglobulins were detected in the sera of 39 (48.8%) patients. All of these patients had cryocrit over 5%. Disease was active in 30 patients [SLEDAI ≥6 (DAI: disease activity index)] and inactive in 50 (SLEDAI <6). There was no significant difference between active and inactive patients for the presence of serum cryoglobulins (r = 0.086, P = 0.56). A significant positive correlation was observed between antinuclear antibody (ANA), anti-dsDNA (dsDNA: Double-stranded deoxyribonucleic acid), CH50 (CH50: total hemolytic complement assay), and C-reactive protein (CRP) (r = 0.21, P = 0.004, r = 0.65, P = 0.001, r = 0.45, P = 0.023, r = 0.38, P = 0.036, respectively). Hepatitis C virus (HCV) infection was not detected in any of the SLE patients. CONCLUSION: Although the presence of cryoglobulins in the SLE patients correlated with positive anti-ds DNA and low CH50, it could not be predict activity of the disease. Medknow Publications & Media Pvt Ltd 2013-03 /pmc/articles/PMC3732906/ /pubmed/23930122 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Karimifar, Mansoor
Pourajam, Samaneh
Tahmasebi, Afshin
Mottaghi, Peyman
Serum cryoglobulins and disease activity in systematic lupus erythematosus
title Serum cryoglobulins and disease activity in systematic lupus erythematosus
title_full Serum cryoglobulins and disease activity in systematic lupus erythematosus
title_fullStr Serum cryoglobulins and disease activity in systematic lupus erythematosus
title_full_unstemmed Serum cryoglobulins and disease activity in systematic lupus erythematosus
title_short Serum cryoglobulins and disease activity in systematic lupus erythematosus
title_sort serum cryoglobulins and disease activity in systematic lupus erythematosus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732906/
https://www.ncbi.nlm.nih.gov/pubmed/23930122
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