Cargando…
Nanocarrier-Mediated Targeting of Tumor and Tumor Vascular Cells Improves Uptake and Penetration of Drugs into Neuroblastoma
Neuroblastoma (NB) is the most common extracranial solid tumor in children, accounting for about 8% of childhood cancers. Despite aggressive treatment, patients suffering from high-risk NB have very poor 5-year overall survival rate, due to relapsed and/or treatment-resistant tumors. A further incre...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733002/ https://www.ncbi.nlm.nih.gov/pubmed/23936762 http://dx.doi.org/10.3389/fonc.2013.00190 |
_version_ | 1782279315490078720 |
---|---|
author | Pastorino, Fabio Brignole, Chiara Loi, Monica Di Paolo, Daniela Di Fiore, Annarita Perri, Patrizia Pagnan, Gabriella Ponzoni, Mirco |
author_facet | Pastorino, Fabio Brignole, Chiara Loi, Monica Di Paolo, Daniela Di Fiore, Annarita Perri, Patrizia Pagnan, Gabriella Ponzoni, Mirco |
author_sort | Pastorino, Fabio |
collection | PubMed |
description | Neuroblastoma (NB) is the most common extracranial solid tumor in children, accounting for about 8% of childhood cancers. Despite aggressive treatment, patients suffering from high-risk NB have very poor 5-year overall survival rate, due to relapsed and/or treatment-resistant tumors. A further increase in therapeutic dose intensity is not feasible, because it will lead to prohibitive short-term and long-term toxicities. New approaches with targeted therapies may improve efficacy and decrease toxicity. The use of drug delivery systems allows site specific delivery of higher payload of active agents associated with lower systemic toxicity compared to the use of conventional (“free”) drugs. The possibility of imparting selectivity to the carriers to the cancer foci through the use of a targeting moiety (e.g., a peptide or an antibody) further enhances drug efficacy and safety. We have recently developed two strategies for increasing local concentration of anti-cancer agents, such as CpG-containing oligonucleotides, small interfering RNAs, and chemotherapeutics in NB. For doing that, we have used the monoclonal antibody anti-disialoganglioside (GD(2)), able to specifically recognize the NB tumor and the peptides containing NGR and CPRECES motifs, that selectively bind to the aminopeptidase N-expressing endothelial and the aminopeptidase A-expressing perivascular tumor cells, respectively. The review will focus on the use of tumor- and tumor vasculature-targeted nanocarriers to improve tumor targeting, uptake, and penetration of drugs in preclinical models of human NB. |
format | Online Article Text |
id | pubmed-3733002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37330022013-08-09 Nanocarrier-Mediated Targeting of Tumor and Tumor Vascular Cells Improves Uptake and Penetration of Drugs into Neuroblastoma Pastorino, Fabio Brignole, Chiara Loi, Monica Di Paolo, Daniela Di Fiore, Annarita Perri, Patrizia Pagnan, Gabriella Ponzoni, Mirco Front Oncol Oncology Neuroblastoma (NB) is the most common extracranial solid tumor in children, accounting for about 8% of childhood cancers. Despite aggressive treatment, patients suffering from high-risk NB have very poor 5-year overall survival rate, due to relapsed and/or treatment-resistant tumors. A further increase in therapeutic dose intensity is not feasible, because it will lead to prohibitive short-term and long-term toxicities. New approaches with targeted therapies may improve efficacy and decrease toxicity. The use of drug delivery systems allows site specific delivery of higher payload of active agents associated with lower systemic toxicity compared to the use of conventional (“free”) drugs. The possibility of imparting selectivity to the carriers to the cancer foci through the use of a targeting moiety (e.g., a peptide or an antibody) further enhances drug efficacy and safety. We have recently developed two strategies for increasing local concentration of anti-cancer agents, such as CpG-containing oligonucleotides, small interfering RNAs, and chemotherapeutics in NB. For doing that, we have used the monoclonal antibody anti-disialoganglioside (GD(2)), able to specifically recognize the NB tumor and the peptides containing NGR and CPRECES motifs, that selectively bind to the aminopeptidase N-expressing endothelial and the aminopeptidase A-expressing perivascular tumor cells, respectively. The review will focus on the use of tumor- and tumor vasculature-targeted nanocarriers to improve tumor targeting, uptake, and penetration of drugs in preclinical models of human NB. Frontiers Media S.A. 2013-08-05 /pmc/articles/PMC3733002/ /pubmed/23936762 http://dx.doi.org/10.3389/fonc.2013.00190 Text en Copyright © 2013 Pastorino, Brignole, Loi, Di Paolo, Di Fiore, Perri, Pagnan and Ponzoni. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Pastorino, Fabio Brignole, Chiara Loi, Monica Di Paolo, Daniela Di Fiore, Annarita Perri, Patrizia Pagnan, Gabriella Ponzoni, Mirco Nanocarrier-Mediated Targeting of Tumor and Tumor Vascular Cells Improves Uptake and Penetration of Drugs into Neuroblastoma |
title | Nanocarrier-Mediated Targeting of Tumor and Tumor Vascular Cells Improves Uptake and Penetration of Drugs into Neuroblastoma |
title_full | Nanocarrier-Mediated Targeting of Tumor and Tumor Vascular Cells Improves Uptake and Penetration of Drugs into Neuroblastoma |
title_fullStr | Nanocarrier-Mediated Targeting of Tumor and Tumor Vascular Cells Improves Uptake and Penetration of Drugs into Neuroblastoma |
title_full_unstemmed | Nanocarrier-Mediated Targeting of Tumor and Tumor Vascular Cells Improves Uptake and Penetration of Drugs into Neuroblastoma |
title_short | Nanocarrier-Mediated Targeting of Tumor and Tumor Vascular Cells Improves Uptake and Penetration of Drugs into Neuroblastoma |
title_sort | nanocarrier-mediated targeting of tumor and tumor vascular cells improves uptake and penetration of drugs into neuroblastoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733002/ https://www.ncbi.nlm.nih.gov/pubmed/23936762 http://dx.doi.org/10.3389/fonc.2013.00190 |
work_keys_str_mv | AT pastorinofabio nanocarriermediatedtargetingoftumorandtumorvascularcellsimprovesuptakeandpenetrationofdrugsintoneuroblastoma AT brignolechiara nanocarriermediatedtargetingoftumorandtumorvascularcellsimprovesuptakeandpenetrationofdrugsintoneuroblastoma AT loimonica nanocarriermediatedtargetingoftumorandtumorvascularcellsimprovesuptakeandpenetrationofdrugsintoneuroblastoma AT dipaolodaniela nanocarriermediatedtargetingoftumorandtumorvascularcellsimprovesuptakeandpenetrationofdrugsintoneuroblastoma AT difioreannarita nanocarriermediatedtargetingoftumorandtumorvascularcellsimprovesuptakeandpenetrationofdrugsintoneuroblastoma AT perripatrizia nanocarriermediatedtargetingoftumorandtumorvascularcellsimprovesuptakeandpenetrationofdrugsintoneuroblastoma AT pagnangabriella nanocarriermediatedtargetingoftumorandtumorvascularcellsimprovesuptakeandpenetrationofdrugsintoneuroblastoma AT ponzonimirco nanocarriermediatedtargetingoftumorandtumorvascularcellsimprovesuptakeandpenetrationofdrugsintoneuroblastoma |