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Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses
Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by impairments in social interaction and communication and restricted and repetitive interests/behaviors. Advances in human genomics have identified a large number of genetic variations associated with ASD. These a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733014/ https://www.ncbi.nlm.nih.gov/pubmed/23935565 http://dx.doi.org/10.3389/fnmol.2013.00019 |
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author | Won, Hyejung Mah, Won Kim, Eunjoon |
author_facet | Won, Hyejung Mah, Won Kim, Eunjoon |
author_sort | Won, Hyejung |
collection | PubMed |
description | Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by impairments in social interaction and communication and restricted and repetitive interests/behaviors. Advances in human genomics have identified a large number of genetic variations associated with ASD. These associations are being rapidly verified by a growing number of studies using a variety of approaches, including mouse genetics. These studies have also identified key mechanisms underlying the pathogenesis of ASD, many of which involve synaptic dysfunctions, and have investigated novel, mechanism-based therapeutic strategies. This review will try to integrate these three key aspects of ASD research: human genetics, animal models, and potential treatments. Continued efforts in this direction should ultimately reveal core mechanisms that account for a larger fraction of ASD cases and identify neural mechanisms associated with specific ASD symptoms, providing important clues to efficient ASD treatment. |
format | Online Article Text |
id | pubmed-3733014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37330142013-08-09 Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses Won, Hyejung Mah, Won Kim, Eunjoon Front Mol Neurosci Neuroscience Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by impairments in social interaction and communication and restricted and repetitive interests/behaviors. Advances in human genomics have identified a large number of genetic variations associated with ASD. These associations are being rapidly verified by a growing number of studies using a variety of approaches, including mouse genetics. These studies have also identified key mechanisms underlying the pathogenesis of ASD, many of which involve synaptic dysfunctions, and have investigated novel, mechanism-based therapeutic strategies. This review will try to integrate these three key aspects of ASD research: human genetics, animal models, and potential treatments. Continued efforts in this direction should ultimately reveal core mechanisms that account for a larger fraction of ASD cases and identify neural mechanisms associated with specific ASD symptoms, providing important clues to efficient ASD treatment. Frontiers Media S.A. 2013-08-05 /pmc/articles/PMC3733014/ /pubmed/23935565 http://dx.doi.org/10.3389/fnmol.2013.00019 Text en Copyright © 2013 Won, Mah and Kim. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Won, Hyejung Mah, Won Kim, Eunjoon Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses |
title | Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses |
title_full | Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses |
title_fullStr | Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses |
title_full_unstemmed | Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses |
title_short | Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses |
title_sort | autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733014/ https://www.ncbi.nlm.nih.gov/pubmed/23935565 http://dx.doi.org/10.3389/fnmol.2013.00019 |
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