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Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors (RRV) in a rodent brain tumor model

In the present study, we compared the therapeutic effect of tumor-selective retroviral replicating vectors (RRV) expressing the yeast cytosine deaminase (CD) delivered by CED or simple injection, followed by systemic administration of the pro-drug, 5-fluorocytosine (5-FC). Treatment with RRV-CD and...

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Detalles Bibliográficos
Autores principales:	Yin, Dali, Zhai, Yuying, Gruber, Harry E., Ibanez, Carlos E., Robbins, Joan M., Kells, Adrian P., Kasahara, Noriyuki, Forsayeth, John, Jolly, Douglas J., Bankiewicz, Krystof S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733370/ https://www.ncbi.nlm.nih.gov/pubmed/23703472 http://dx.doi.org/10.1038/cgt.2013.25

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