Has the circulating permeability factor in primary FSGS been found?

A circulating permeability factor has long been implicated in the pathogenesis of primary focal segmental glomerulosclerosis (FSGS). Recent evidence in animal models, and now in several cohorts of patients with primary FSGS, suggest that the soluble urokinase-type plasminogen-activator receptor (suPAR) might fulfill at least a role as biomarker and perhaps even as contributing factor. Although ongoing studies are needed, confirmation of these findings might lead to new diagnostic and therapeutic strategies for this often resistant glomerular disease, as well as a better understanding of podocyte dysfunction.