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Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30

BACKGROUND: The genetic basis for avian to mammalian host switching in influenza A virus is largely unknown. The human A/HK/156/1997 (H5N1) virus that transmitted from poultry possesses NS1 gene mutations F103L + M106I that are virulence determinants in the mouse model of pneumonia; however their in...

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Detalles Bibliográficos
Autores principales:	Dankar, Samar K, Miranda, Elena, Forbes, Nicole E, Pelchat, Martin, Tavassoli, Ali, Selman, Mohammed, Ping, Jihui, Jia, Jianjun, Brown, Earl G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733596/ https://www.ncbi.nlm.nih.gov/pubmed/23886034 http://dx.doi.org/10.1186/1743-422X-10-243

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