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Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes

Pyruvate dehydrogenase kinases (PDK1-4) play a critical role in the inhibition of the mitochondrial pyruvate dehydrogenase complex especially when blood glucose levels are low and pyruvate can be conserved for gluconeogenesis. Under diabetic conditions, the Pdk genes, particularly Pdk4, are often in...

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Detalles Bibliográficos
Autores principales:	Tao, Rongya, Xiong, Xiwen, Harris, Robert A., White, Morris F., Dong, Xiaocheng C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733847/ https://www.ncbi.nlm.nih.gov/pubmed/23940800 http://dx.doi.org/10.1371/journal.pone.0071997

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