Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents

Several new therapeutic strategies are now considered for acute myeloid leukemia (AML) patients unfit for intensive chemotherapy, including modulation of protein lysine acetylation through inhibition of histone deacetylases (HDACs). These enzymes alter the acetylation of several proteins, including...

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Detalles Bibliográficos
Autores principales: Fredly, Hanne, Gjertsen, Bjørn Tore, Bruserud, Øystein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733883/
https://www.ncbi.nlm.nih.gov/pubmed/23898968
http://dx.doi.org/10.1186/1868-7083-5-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733883/
https://www.ncbi.nlm.nih.gov/pubmed/23898968
http://dx.doi.org/10.1186/1868-7083-5-12

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