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Exercise-Induced Blood Lactate Increase Does Not Change Red Blood Cell Deformability in Cyclists

BACKGROUND: The effect of exercise-induced lactate production on red blood cell deformability and other blood rheological changes is controversial, given heavy-exercise induces biochemical processes (e.g., oxidative stress) known to perturb haemorheology. The aim of the present study was to examine...

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Autores principales: Simmonds, Michael J., Connes, Philippe, Sabapathy, Surendran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733956/
https://www.ncbi.nlm.nih.gov/pubmed/23940722
http://dx.doi.org/10.1371/journal.pone.0071219
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author Simmonds, Michael J.
Connes, Philippe
Sabapathy, Surendran
author_facet Simmonds, Michael J.
Connes, Philippe
Sabapathy, Surendran
author_sort Simmonds, Michael J.
collection PubMed
description BACKGROUND: The effect of exercise-induced lactate production on red blood cell deformability and other blood rheological changes is controversial, given heavy-exercise induces biochemical processes (e.g., oxidative stress) known to perturb haemorheology. The aim of the present study was to examine the haemorheological response to a short-duration cycling protocol designed to increase blood lactate concentration, but of duration insufficient to induce significant oxidative stress. METHODS: Male cyclists and triathletes (n = 6; 27±7 yr; body mass index: 23.7±3.0 kg/m(2); peak oxygen uptake 4.02±0.51 L/min) performed unloaded (0 W), moderate-intensity, and heavy-intensity cycling. Blood was sampled at rest and during the final minute of each cycling bout. Blood chemistry, blood viscosity, red blood cell aggregation and red blood cell deformability were measured. RESULTS: Blood lactate concentration increased significantly during heavy-intensity cycling, when compared with all other conditions. Methaemoglobin fraction did not change during any exercise bout when compared with rest. Blood viscosity at native haematocrit increased during heavy-intensity cycling at higher-shear rates when compared with rest, unloaded and moderate-intensity cycling. Heavy-intensity exercise increased the amplitude of red blood cell aggregation in native haematocrit samples when compared with all other conditions. Red blood cell deformability was not changed by exercise. CONCLUSION: Acute exercise perturbs haemorheology in an intensity dose-response fashion; however, many of the haemorheological effects appear to be secondary to haemoconcentration, rather than increased lactate concentration.
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spelling pubmed-37339562013-08-12 Exercise-Induced Blood Lactate Increase Does Not Change Red Blood Cell Deformability in Cyclists Simmonds, Michael J. Connes, Philippe Sabapathy, Surendran PLoS One Research Article BACKGROUND: The effect of exercise-induced lactate production on red blood cell deformability and other blood rheological changes is controversial, given heavy-exercise induces biochemical processes (e.g., oxidative stress) known to perturb haemorheology. The aim of the present study was to examine the haemorheological response to a short-duration cycling protocol designed to increase blood lactate concentration, but of duration insufficient to induce significant oxidative stress. METHODS: Male cyclists and triathletes (n = 6; 27±7 yr; body mass index: 23.7±3.0 kg/m(2); peak oxygen uptake 4.02±0.51 L/min) performed unloaded (0 W), moderate-intensity, and heavy-intensity cycling. Blood was sampled at rest and during the final minute of each cycling bout. Blood chemistry, blood viscosity, red blood cell aggregation and red blood cell deformability were measured. RESULTS: Blood lactate concentration increased significantly during heavy-intensity cycling, when compared with all other conditions. Methaemoglobin fraction did not change during any exercise bout when compared with rest. Blood viscosity at native haematocrit increased during heavy-intensity cycling at higher-shear rates when compared with rest, unloaded and moderate-intensity cycling. Heavy-intensity exercise increased the amplitude of red blood cell aggregation in native haematocrit samples when compared with all other conditions. Red blood cell deformability was not changed by exercise. CONCLUSION: Acute exercise perturbs haemorheology in an intensity dose-response fashion; however, many of the haemorheological effects appear to be secondary to haemoconcentration, rather than increased lactate concentration. Public Library of Science 2013-08-05 /pmc/articles/PMC3733956/ /pubmed/23940722 http://dx.doi.org/10.1371/journal.pone.0071219 Text en © 2013 Simmonds et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Simmonds, Michael J.
Connes, Philippe
Sabapathy, Surendran
Exercise-Induced Blood Lactate Increase Does Not Change Red Blood Cell Deformability in Cyclists
title Exercise-Induced Blood Lactate Increase Does Not Change Red Blood Cell Deformability in Cyclists
title_full Exercise-Induced Blood Lactate Increase Does Not Change Red Blood Cell Deformability in Cyclists
title_fullStr Exercise-Induced Blood Lactate Increase Does Not Change Red Blood Cell Deformability in Cyclists
title_full_unstemmed Exercise-Induced Blood Lactate Increase Does Not Change Red Blood Cell Deformability in Cyclists
title_short Exercise-Induced Blood Lactate Increase Does Not Change Red Blood Cell Deformability in Cyclists
title_sort exercise-induced blood lactate increase does not change red blood cell deformability in cyclists
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733956/
https://www.ncbi.nlm.nih.gov/pubmed/23940722
http://dx.doi.org/10.1371/journal.pone.0071219
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