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Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies

BACKGROUND: PQS (PseudomonasQuinolone Signal) and its precursor HHQ are signal molecules of the P. aeruginosa quorum sensing system. They explicate their role in mammalian pathogenicity by binding to the receptor PqsR that induces virulence factor production and biofilm formation. The enzyme PqsD ca...

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Detalles Bibliográficos
Autores principales:	Steinbach, Anke, Maurer, Christine K, Weidel, Elisabeth, Henn, Claudia, Brengel, Christian, Hartmann, Rolf W, Negri, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734052/ https://www.ncbi.nlm.nih.gov/pubmed/23916145 http://dx.doi.org/10.1186/2046-1682-6-10

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