Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs

In response to inflammation, pancreatic acinar cells can undergo acinar-to-ductal metaplasia (ADM), a reprogramming event that induces transdifferentiation to a ductlike phenotype and, in the context of additional oncogenic stimulation, contributes to development of pancreatic cancer. The signaling...

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Detalles Bibliográficos
Autores principales: Liou, Geou-Yarh, Döppler, Heike, Necela, Brian, Krishna, Murli, Crawford, Howard C., Raimondo, Massimo, Storz, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734091/
https://www.ncbi.nlm.nih.gov/pubmed/23918941
http://dx.doi.org/10.1083/jcb.201301001

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