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A compendium of molecules involved in vector-pathogen interactions pertaining to malaria
Malaria is a vector-borne disease causing extensive morbidity, debility and mortality. Development of resistance to drugs among parasites and to conventional insecticides among vector-mosquitoes necessitates innovative measures to combat this disease. Identification of molecules involved in the main...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734095/ https://www.ncbi.nlm.nih.gov/pubmed/23802619 http://dx.doi.org/10.1186/1475-2875-12-216 |
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author | Sreenivasamurthy, Sreelakshmi K Dey, Gourav Ramu, Manjula Kumar, Manish Gupta, Manoj K Mohanty, Ajeet K Harsha, HC Sharma, Pushkar Kumar, Nirbhay Pandey, Akhilesh Kumar, Ashwani Prasad, TS Keshava |
author_facet | Sreenivasamurthy, Sreelakshmi K Dey, Gourav Ramu, Manjula Kumar, Manish Gupta, Manoj K Mohanty, Ajeet K Harsha, HC Sharma, Pushkar Kumar, Nirbhay Pandey, Akhilesh Kumar, Ashwani Prasad, TS Keshava |
author_sort | Sreenivasamurthy, Sreelakshmi K |
collection | PubMed |
description | Malaria is a vector-borne disease causing extensive morbidity, debility and mortality. Development of resistance to drugs among parasites and to conventional insecticides among vector-mosquitoes necessitates innovative measures to combat this disease. Identification of molecules involved in the maintenance of complex developmental cycles of the parasites within the vector and the host can provide attractive targets to intervene in the disease transmission. In the last decade, several efforts have been made in identifying such molecules involved in mosquito-parasite interactions and, subsequently, validating their role in the development of parasites within the vector. In this study, a list of mosquito proteins, which facilitate or inhibit the development of malaria parasites in the midgut, haemolymph and salivary glands of mosquitoes, is compiled. A total of 94 molecules have been reported and validated for their role in the development of malaria parasites inside the vector. This compendium of molecules will serve as a centralized resource to biomedical researchers investigating vector-pathogen interactions and malaria transmission. |
format | Online Article Text |
id | pubmed-3734095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-37340952013-08-06 A compendium of molecules involved in vector-pathogen interactions pertaining to malaria Sreenivasamurthy, Sreelakshmi K Dey, Gourav Ramu, Manjula Kumar, Manish Gupta, Manoj K Mohanty, Ajeet K Harsha, HC Sharma, Pushkar Kumar, Nirbhay Pandey, Akhilesh Kumar, Ashwani Prasad, TS Keshava Malar J Review Malaria is a vector-borne disease causing extensive morbidity, debility and mortality. Development of resistance to drugs among parasites and to conventional insecticides among vector-mosquitoes necessitates innovative measures to combat this disease. Identification of molecules involved in the maintenance of complex developmental cycles of the parasites within the vector and the host can provide attractive targets to intervene in the disease transmission. In the last decade, several efforts have been made in identifying such molecules involved in mosquito-parasite interactions and, subsequently, validating their role in the development of parasites within the vector. In this study, a list of mosquito proteins, which facilitate or inhibit the development of malaria parasites in the midgut, haemolymph and salivary glands of mosquitoes, is compiled. A total of 94 molecules have been reported and validated for their role in the development of malaria parasites inside the vector. This compendium of molecules will serve as a centralized resource to biomedical researchers investigating vector-pathogen interactions and malaria transmission. BioMed Central 2013-06-26 /pmc/articles/PMC3734095/ /pubmed/23802619 http://dx.doi.org/10.1186/1475-2875-12-216 Text en Copyright © 2013 Sreenivasamurthy et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Sreenivasamurthy, Sreelakshmi K Dey, Gourav Ramu, Manjula Kumar, Manish Gupta, Manoj K Mohanty, Ajeet K Harsha, HC Sharma, Pushkar Kumar, Nirbhay Pandey, Akhilesh Kumar, Ashwani Prasad, TS Keshava A compendium of molecules involved in vector-pathogen interactions pertaining to malaria |
title | A compendium of molecules involved in vector-pathogen interactions pertaining to malaria |
title_full | A compendium of molecules involved in vector-pathogen interactions pertaining to malaria |
title_fullStr | A compendium of molecules involved in vector-pathogen interactions pertaining to malaria |
title_full_unstemmed | A compendium of molecules involved in vector-pathogen interactions pertaining to malaria |
title_short | A compendium of molecules involved in vector-pathogen interactions pertaining to malaria |
title_sort | compendium of molecules involved in vector-pathogen interactions pertaining to malaria |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734095/ https://www.ncbi.nlm.nih.gov/pubmed/23802619 http://dx.doi.org/10.1186/1475-2875-12-216 |
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