Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation

OBJECTIVES: Activation of RhoA/Rho-kinase (ROCK) is increasingly implicated in acute vasospasm and chronic vasoconstriction in major organ systems. Therefore we aimed to ascertain whether an increase in ROCK activity plays a role in the deterioration of coronary vascular function in early stage diab...

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Detalles Bibliográficos
Autores principales: Pearson, James T, Jenkins, Mathew J, Edgley, Amanda J, Sonobe, Takashi, Joshi, Mandar, Waddingham, Mark T, Fujii, Yutaka, Schwenke, Daryl O, Tsuchimochi, Hirotsugu, Yoshimoto, Misa, Umetani, Keiji, Kelly, Darren J, Shirai, Mikiyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734116/
https://www.ncbi.nlm.nih.gov/pubmed/24059472
http://dx.doi.org/10.1186/1475-2840-12-111

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