Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones

Adult neurogenesis in female mice is known to be enhanced by exposure to soiled bedding from males, although the identity of the relevant chemosignals has remained unknown. Here we show that the previously recognized male murine pheromones, the farnesenes and 2-sec-butyl-4,5-dihydrothiazole (SBT), s...

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Autores principales: Koyama, Sachiko, Soini, Helena A., Foley, John, Novotny, Milos V., Lai, Cary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734356/
https://www.ncbi.nlm.nih.gov/pubmed/23964214
http://dx.doi.org/10.3389/fnbeh.2013.00101
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author Koyama, Sachiko
Soini, Helena A.
Foley, John
Novotny, Milos V.
Lai, Cary
author_facet Koyama, Sachiko
Soini, Helena A.
Foley, John
Novotny, Milos V.
Lai, Cary
author_sort Koyama, Sachiko
collection PubMed
description Adult neurogenesis in female mice is known to be enhanced by exposure to soiled bedding from males, although the identity of the relevant chemosignals has remained unknown. Here we show that the previously recognized male murine pheromones, the farnesenes and 2-sec-butyl-4,5-dihydrothiazole (SBT), strongly increase cell proliferation in the subventricular zone (SVZ) of adult female mice, but not younger female mice. In addition, we found that a unique female murine pheromone, 2,5-dimethylpyrazine, facilitates similar changes in males. SBT stimulated cell proliferation in the SVZ of only adult females and not in young adult or pre- and post-puberty females. Our study suggests that pheromonal communication between males and females is enhancing reproductive success by controlling the estrous cycle and by promoting cell proliferation in a reciprocal manner.
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spelling pubmed-37343562013-08-20 Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones Koyama, Sachiko Soini, Helena A. Foley, John Novotny, Milos V. Lai, Cary Front Behav Neurosci Neuroscience Adult neurogenesis in female mice is known to be enhanced by exposure to soiled bedding from males, although the identity of the relevant chemosignals has remained unknown. Here we show that the previously recognized male murine pheromones, the farnesenes and 2-sec-butyl-4,5-dihydrothiazole (SBT), strongly increase cell proliferation in the subventricular zone (SVZ) of adult female mice, but not younger female mice. In addition, we found that a unique female murine pheromone, 2,5-dimethylpyrazine, facilitates similar changes in males. SBT stimulated cell proliferation in the SVZ of only adult females and not in young adult or pre- and post-puberty females. Our study suggests that pheromonal communication between males and females is enhancing reproductive success by controlling the estrous cycle and by promoting cell proliferation in a reciprocal manner. Frontiers Media S.A. 2013-08-06 /pmc/articles/PMC3734356/ /pubmed/23964214 http://dx.doi.org/10.3389/fnbeh.2013.00101 Text en Copyright © 2013 Koyama, Soini, Foley, Novotny and Lai. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Koyama, Sachiko
Soini, Helena A.
Foley, John
Novotny, Milos V.
Lai, Cary
Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones
title Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones
title_full Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones
title_fullStr Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones
title_full_unstemmed Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones
title_short Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones
title_sort stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734356/
https://www.ncbi.nlm.nih.gov/pubmed/23964214
http://dx.doi.org/10.3389/fnbeh.2013.00101
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