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CD8αα Expression Marks Terminally Differentiated Human CD8+ T Cells Expanded in Chronic Viral Infection

The T cell co-receptor CD8αβ enhances T cell sensitivity to antigen, however studies indicate CD8αα has the converse effect and acts as a co-repressor. Using a combination of Thymic Leukemia (TL) antigen tetramer, which directly binds CD8αα, anti-CD161, and anti-Vα7.2 antibodies we have been able fo...

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Detalles Bibliográficos
Autores principales:	Walker, L. J., Marrinan, E., Muenchhoff, M., Ferguson, J., Kloverpris, H., Cheroutre, H., Barnes, E., Goulder, P., Klenerman, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734367/ https://www.ncbi.nlm.nih.gov/pubmed/23964274 http://dx.doi.org/10.3389/fimmu.2013.00223

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