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Age-dependent yield of screening for undetected atrial fibrillation in stroke patients: the Find-AF study

Diagnosis of paroxysmal atrial fibrillation (AF) in stroke patients is challenging, but highly clinically relevant. The percentage of stroke patients with permanent AF increases with age, but limited data are available for the age-dependent yield of paroxysmal AF by Holter monitoring. Patients with...

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Autores principales: Wachter, Rolf, Weber-Krüger, Mark, Seegers, Joachim, Edelmann, Frank, Wohlfahrt, Janin, Wasser, Katrin, Gelbrich, Götz, Hasenfuß, Gerd, Stahrenberg, Raoul, Liman, Jan, Gröschel, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734596/
https://www.ncbi.nlm.nih.gov/pubmed/23632947
http://dx.doi.org/10.1007/s00415-013-6935-x
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author Wachter, Rolf
Weber-Krüger, Mark
Seegers, Joachim
Edelmann, Frank
Wohlfahrt, Janin
Wasser, Katrin
Gelbrich, Götz
Hasenfuß, Gerd
Stahrenberg, Raoul
Liman, Jan
Gröschel, Klaus
author_facet Wachter, Rolf
Weber-Krüger, Mark
Seegers, Joachim
Edelmann, Frank
Wohlfahrt, Janin
Wasser, Katrin
Gelbrich, Götz
Hasenfuß, Gerd
Stahrenberg, Raoul
Liman, Jan
Gröschel, Klaus
author_sort Wachter, Rolf
collection PubMed
description Diagnosis of paroxysmal atrial fibrillation (AF) in stroke patients is challenging, but highly clinically relevant. The percentage of stroke patients with permanent AF increases with age, but limited data are available for the age-dependent yield of paroxysmal AF by Holter monitoring. Patients with acute cerebral ischemia were included into the prospective observational Find-AF study. Patients free from AF at presentation received 7 day Holter monitoring. We calculated the percentage of otherwise undetected paroxysmal AF and the number needed to screen for age groups under 60 years, and in 5 year clusters from the age of 60 up to 85 and older. 272 patients were included, 43 (15.8 %) had AF at admission, 33 patients with paroxysmal AF were identified by 7 day Holter (n = 29) or medical history (n = 4).The yield of 7 day Holter ECG clearly increased with older age (p = 0.004): <60 years: 5 %, 60–64 years: 5 %, 65–69 years: 7 %, 70–74 years: 11 %, 75–79 years: 13 %, 80–84 years: 25 %, ≥85 years: 39 %. The number needed to screen (NNS) to find one patient with paroxysmal AF decreased with age: ≤60 years: 18, 60–64 years: 20, 65–69 years: 14, 70–74 years: 9, 75–79 years: 8, 80–84 years: 4, ≥85 years: 3, respectively. In patients <65 years, all AF cases were detected by Holter ECG. The percentage of paroxysmal AF in stroke patients increases with age. The 7 day Holter ECG is most efficient in elderly patients.
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spelling pubmed-37345962013-08-08 Age-dependent yield of screening for undetected atrial fibrillation in stroke patients: the Find-AF study Wachter, Rolf Weber-Krüger, Mark Seegers, Joachim Edelmann, Frank Wohlfahrt, Janin Wasser, Katrin Gelbrich, Götz Hasenfuß, Gerd Stahrenberg, Raoul Liman, Jan Gröschel, Klaus J Neurol Original Communication Diagnosis of paroxysmal atrial fibrillation (AF) in stroke patients is challenging, but highly clinically relevant. The percentage of stroke patients with permanent AF increases with age, but limited data are available for the age-dependent yield of paroxysmal AF by Holter monitoring. Patients with acute cerebral ischemia were included into the prospective observational Find-AF study. Patients free from AF at presentation received 7 day Holter monitoring. We calculated the percentage of otherwise undetected paroxysmal AF and the number needed to screen for age groups under 60 years, and in 5 year clusters from the age of 60 up to 85 and older. 272 patients were included, 43 (15.8 %) had AF at admission, 33 patients with paroxysmal AF were identified by 7 day Holter (n = 29) or medical history (n = 4).The yield of 7 day Holter ECG clearly increased with older age (p = 0.004): <60 years: 5 %, 60–64 years: 5 %, 65–69 years: 7 %, 70–74 years: 11 %, 75–79 years: 13 %, 80–84 years: 25 %, ≥85 years: 39 %. The number needed to screen (NNS) to find one patient with paroxysmal AF decreased with age: ≤60 years: 18, 60–64 years: 20, 65–69 years: 14, 70–74 years: 9, 75–79 years: 8, 80–84 years: 4, ≥85 years: 3, respectively. In patients <65 years, all AF cases were detected by Holter ECG. The percentage of paroxysmal AF in stroke patients increases with age. The 7 day Holter ECG is most efficient in elderly patients. Springer Berlin Heidelberg 2013-05-01 2013 /pmc/articles/PMC3734596/ /pubmed/23632947 http://dx.doi.org/10.1007/s00415-013-6935-x Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Communication
Wachter, Rolf
Weber-Krüger, Mark
Seegers, Joachim
Edelmann, Frank
Wohlfahrt, Janin
Wasser, Katrin
Gelbrich, Götz
Hasenfuß, Gerd
Stahrenberg, Raoul
Liman, Jan
Gröschel, Klaus
Age-dependent yield of screening for undetected atrial fibrillation in stroke patients: the Find-AF study
title Age-dependent yield of screening for undetected atrial fibrillation in stroke patients: the Find-AF study
title_full Age-dependent yield of screening for undetected atrial fibrillation in stroke patients: the Find-AF study
title_fullStr Age-dependent yield of screening for undetected atrial fibrillation in stroke patients: the Find-AF study
title_full_unstemmed Age-dependent yield of screening for undetected atrial fibrillation in stroke patients: the Find-AF study
title_short Age-dependent yield of screening for undetected atrial fibrillation in stroke patients: the Find-AF study
title_sort age-dependent yield of screening for undetected atrial fibrillation in stroke patients: the find-af study
topic Original Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734596/
https://www.ncbi.nlm.nih.gov/pubmed/23632947
http://dx.doi.org/10.1007/s00415-013-6935-x
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