Cargando…
Integration of transient receptor potential canonical channels with lipids
Transient receptor potential canonical (TRPC) channels are the canonical (C) subset of the TRP proteins, which are widely expressed in mammalian cells. They are thought to be primarily involved in determining calcium and sodium entry and have wide-ranging functions that include regulation of cell pr...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734623/ https://www.ncbi.nlm.nih.gov/pubmed/21624095 http://dx.doi.org/10.1111/j.1748-1716.2011.02311.x |
_version_ | 1782279559879589888 |
---|---|
author | Beech, D J |
author_facet | Beech, D J |
author_sort | Beech, D J |
collection | PubMed |
description | Transient receptor potential canonical (TRPC) channels are the canonical (C) subset of the TRP proteins, which are widely expressed in mammalian cells. They are thought to be primarily involved in determining calcium and sodium entry and have wide-ranging functions that include regulation of cell proliferation, motility and contraction. The channels are modulated by a multiplicity of factors, putatively existing as integrators in the plasma membrane. This review considers the sensitivities of TRPC channels to lipids that include diacylglycerols, phosphatidylinositol bisphosphate, lysophospholipids, oxidized phospholipids, arachidonic acid and its metabolites, sphingosine-1-phosphate, cholesterol and some steroidal derivatives and other lipid factors such as gangliosides. Promiscuous and selective lipid sensing have been detected. There appear to be close working relationships with lipids of the phospholipase C and A(2) enzyme systems, which may enable integration with receptor signalling and membrane stretch. There are differences in the properties of each TRPC channel that are further complicated by TRPC heteromultimerization. The lipids modulate activity of the channels or insertion in the plasma membrane. Lipid microenvironments and intermediate sensing proteins have been described that include caveolae, G protein signalling, SEC14-like and spectrin-type domains 1 (SESTD1) and podocin. The data suggest that lipid sensing is an important aspect of TRPC channel biology enabling integration with other signalling systems. |
format | Online Article Text |
id | pubmed-3734623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37346232013-08-07 Integration of transient receptor potential canonical channels with lipids Beech, D J Acta Physiol (Oxf) Reviews Transient receptor potential canonical (TRPC) channels are the canonical (C) subset of the TRP proteins, which are widely expressed in mammalian cells. They are thought to be primarily involved in determining calcium and sodium entry and have wide-ranging functions that include regulation of cell proliferation, motility and contraction. The channels are modulated by a multiplicity of factors, putatively existing as integrators in the plasma membrane. This review considers the sensitivities of TRPC channels to lipids that include diacylglycerols, phosphatidylinositol bisphosphate, lysophospholipids, oxidized phospholipids, arachidonic acid and its metabolites, sphingosine-1-phosphate, cholesterol and some steroidal derivatives and other lipid factors such as gangliosides. Promiscuous and selective lipid sensing have been detected. There appear to be close working relationships with lipids of the phospholipase C and A(2) enzyme systems, which may enable integration with receptor signalling and membrane stretch. There are differences in the properties of each TRPC channel that are further complicated by TRPC heteromultimerization. The lipids modulate activity of the channels or insertion in the plasma membrane. Lipid microenvironments and intermediate sensing proteins have been described that include caveolae, G protein signalling, SEC14-like and spectrin-type domains 1 (SESTD1) and podocin. The data suggest that lipid sensing is an important aspect of TRPC channel biology enabling integration with other signalling systems. Blackwell Publishing Ltd 2012-02 /pmc/articles/PMC3734623/ /pubmed/21624095 http://dx.doi.org/10.1111/j.1748-1716.2011.02311.x Text en © 2011 The Author. Acta Physiologica © 2011 Scandinavian Physiological Society http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Reviews Beech, D J Integration of transient receptor potential canonical channels with lipids |
title | Integration of transient receptor potential canonical channels with lipids |
title_full | Integration of transient receptor potential canonical channels with lipids |
title_fullStr | Integration of transient receptor potential canonical channels with lipids |
title_full_unstemmed | Integration of transient receptor potential canonical channels with lipids |
title_short | Integration of transient receptor potential canonical channels with lipids |
title_sort | integration of transient receptor potential canonical channels with lipids |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734623/ https://www.ncbi.nlm.nih.gov/pubmed/21624095 http://dx.doi.org/10.1111/j.1748-1716.2011.02311.x |
work_keys_str_mv | AT beechdj integrationoftransientreceptorpotentialcanonicalchannelswithlipids |