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The design and development of a stented tissue mitral and aortic heart valve replacement for human implantation

ABSTRACT: A study was conducted into the development of a mitral and aortic heart valve replacement that caters for patients having suffered valve damage due to stenosis or rheumatic fever. The appeal of the valve is that it is constituted from a solid frame housing pericardial tissue leaflets, and...

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Detalles Bibliográficos
Autores principales: Legg, Murray, Mathews, Edward, Pelzer, Ruaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734742/
https://www.ncbi.nlm.nih.gov/pubmed/22555635
http://dx.doi.org/10.5830/CVJA-2010-065
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author Legg, Murray
Mathews, Edward
Pelzer, Ruaan
author_facet Legg, Murray
Mathews, Edward
Pelzer, Ruaan
author_sort Legg, Murray
collection PubMed
description ABSTRACT: A study was conducted into the development of a mitral and aortic heart valve replacement that caters for patients having suffered valve damage due to stenosis or rheumatic fever. The appeal of the valve is that it is constituted from a solid frame housing pericardial tissue leaflets, and allows the patient freedom from post-operative blood-thinning medication. The valve is designed to appeal to patients in developing areas of the world, as it features a clip-in mechanism to secure the valve assembly into the sewing ring, which is stitched in independently of the frame and leaflets. Re-operative valve replacement would then be made possible when the pericardial leaflets began to calcify. Novel aspects of the design added value to the science of heart valve replacements, through the use of sintered chrome cobalt in the valve components, the insights gained into mechanical testing of pericardium, and the patient benefits offered by the complete design. Further work is planned to fatigue test the assembly, undergo animal trials and make the valve available for commercial use.
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spelling pubmed-37347422013-08-07 The design and development of a stented tissue mitral and aortic heart valve replacement for human implantation Legg, Murray Mathews, Edward Pelzer, Ruaan Cardiovasc J Afr Cardiovascular Topics ABSTRACT: A study was conducted into the development of a mitral and aortic heart valve replacement that caters for patients having suffered valve damage due to stenosis or rheumatic fever. The appeal of the valve is that it is constituted from a solid frame housing pericardial tissue leaflets, and allows the patient freedom from post-operative blood-thinning medication. The valve is designed to appeal to patients in developing areas of the world, as it features a clip-in mechanism to secure the valve assembly into the sewing ring, which is stitched in independently of the frame and leaflets. Re-operative valve replacement would then be made possible when the pericardial leaflets began to calcify. Novel aspects of the design added value to the science of heart valve replacements, through the use of sintered chrome cobalt in the valve components, the insights gained into mechanical testing of pericardium, and the patient benefits offered by the complete design. Further work is planned to fatigue test the assembly, undergo animal trials and make the valve available for commercial use. Clinics Cardive Publishing 2012-04 /pmc/articles/PMC3734742/ /pubmed/22555635 http://dx.doi.org/10.5830/CVJA-2010-065 Text en Copyright © 2010 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cardiovascular Topics
Legg, Murray
Mathews, Edward
Pelzer, Ruaan
The design and development of a stented tissue mitral and aortic heart valve replacement for human implantation
title The design and development of a stented tissue mitral and aortic heart valve replacement for human implantation
title_full The design and development of a stented tissue mitral and aortic heart valve replacement for human implantation
title_fullStr The design and development of a stented tissue mitral and aortic heart valve replacement for human implantation
title_full_unstemmed The design and development of a stented tissue mitral and aortic heart valve replacement for human implantation
title_short The design and development of a stented tissue mitral and aortic heart valve replacement for human implantation
title_sort design and development of a stented tissue mitral and aortic heart valve replacement for human implantation
topic Cardiovascular Topics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734742/
https://www.ncbi.nlm.nih.gov/pubmed/22555635
http://dx.doi.org/10.5830/CVJA-2010-065
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