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Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil

5-Fluorouracil (5-FU) is the first rationally designed antimetabolite, which achieves its therapeutic efficacy through inhibition of the enzyme thymidylate synthase (TS), which is essential for the synthesis and repair of DNA. However, prolonged exposure to 5-FU induces TS overexpression, which lead...

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Detalles Bibliográficos
Autores principales:	Vinod, B S, Antony, J, Nair, H H, Puliyappadamba, V T, Saikia, M, Shyam Narayanan, S, Bevin, A, John Anto, R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734809/ https://www.ncbi.nlm.nih.gov/pubmed/23429291 http://dx.doi.org/10.1038/cddis.2013.26

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