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Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression

VRK2 is a novel Ser-Thr kinase whose VRK2A isoform is located in the endoplasmic reticulum and mitochondrial membranes. We have studied the potential role that VRK2A has in the regulation of mitochondrial-mediated apoptosis. VRK2A can regulate the intrinsic apoptotic pathway in two different ways. T...

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Detalles Bibliográficos
Autores principales:	Monsalve, D M, Merced, T, Fernández, I F, Blanco, S, Vázquez-Cedeira, M, Lazo, P A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734818/ https://www.ncbi.nlm.nih.gov/pubmed/23449449 http://dx.doi.org/10.1038/cddis.2013.40

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