Neuroglobin upregulation induced by 17β-estradiol sequesters cytocrome c in the mitochondria preventing H(2)O(2)-induced apoptosis of neuroblastoma cells

The sex steroid hormone 17β-estradiol (E2) upregulates the levels of neuroglobin (NGB), a new neuroprotectant globin, to elicit its neuroprotective effect against H(2)O(2)-induced apoptosis. Several mechanisms could be proposed to justify the NGB involvement in E2 prevention of stress-induced apopto...

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Detalles Bibliográficos
Autores principales: De Marinis, E, Fiocchetti, M, Acconcia, F, Ascenzi, P, Marino, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734830/
https://www.ncbi.nlm.nih.gov/pubmed/23429294
http://dx.doi.org/10.1038/cddis.2013.30

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