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No Correlation Between Interleukin-10 Gene Promoter Polymorphisms and Hepatitis B Virus Infection Outcome

BACKGROUND: Single nucleotide polymorphisms (SNP) in the promoter region of the interleukin (IL)-10 genes have a role in determining hepatitis B virus (HBV) outcome. OBJECTIVES: This study evaluates the correlation between HBV infection and SNP in IL-10 gene promoter. PATIENTS AND METHODS: Ninety-si...

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Autores principales: Sofian, Masoomeh, Kalantar, Ebrahim, Aghakhani, Arezoo, Hosseini, Soudabeh, Banifazl, Mohammad, Eslamifar, Ali, jourabchi, Ali, Farazi, Ali Asghar, Ramezani, Amitis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734898/
https://www.ncbi.nlm.nih.gov/pubmed/23922563
http://dx.doi.org/10.5812/hepatmon.8803
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author Sofian, Masoomeh
Kalantar, Ebrahim
Aghakhani, Arezoo
Hosseini, Soudabeh
Banifazl, Mohammad
Eslamifar, Ali
jourabchi, Ali
Farazi, Ali Asghar
Ramezani, Amitis
author_facet Sofian, Masoomeh
Kalantar, Ebrahim
Aghakhani, Arezoo
Hosseini, Soudabeh
Banifazl, Mohammad
Eslamifar, Ali
jourabchi, Ali
Farazi, Ali Asghar
Ramezani, Amitis
author_sort Sofian, Masoomeh
collection PubMed
description BACKGROUND: Single nucleotide polymorphisms (SNP) in the promoter region of the interleukin (IL)-10 genes have a role in determining hepatitis B virus (HBV) outcome. OBJECTIVES: This study evaluates the correlation between HBV infection and SNP in IL-10 gene promoter. PATIENTS AND METHODS: Ninety-six HBV-infected patients (32 chronic hepatitis B infection patients, 34 healthy carriers, 30 spontaneously recovered cases) and 31 healthy controls were enrolled. Three biallelic (-819,-592,-1082) regions in the IL-10 gene promoter were sequenced for all patients. RESULTS: Genotypes and haplotypes of IL-10 gene promoter region at position -1082, -819 and -592 were not significantly different among controls, HBV recovered cases, carriers and chronic HBV patients. Nevertheless, A/A genotype at position -592 and T/T genotype at position -819 were more frequently seen in the HBV clearance group, while frequency of G/G genotype at position -1082 was more prevalent in the persistence group. GCC/GCC and GCC/ACC haplotypes were significantly observed in anti-HBe positive individuals. CONCLUSIONS: Our findings showed that IL-10 promoter polymorphisms were not correlated with HBV infection prognosis. Nevertheless, individuals carrying high and intermediate producer of IL-10 haplotypes had a better ability to develop anti-HBe than low producer carriers.
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spelling pubmed-37348982013-08-06 No Correlation Between Interleukin-10 Gene Promoter Polymorphisms and Hepatitis B Virus Infection Outcome Sofian, Masoomeh Kalantar, Ebrahim Aghakhani, Arezoo Hosseini, Soudabeh Banifazl, Mohammad Eslamifar, Ali jourabchi, Ali Farazi, Ali Asghar Ramezani, Amitis Hepat Mon Research Article BACKGROUND: Single nucleotide polymorphisms (SNP) in the promoter region of the interleukin (IL)-10 genes have a role in determining hepatitis B virus (HBV) outcome. OBJECTIVES: This study evaluates the correlation between HBV infection and SNP in IL-10 gene promoter. PATIENTS AND METHODS: Ninety-six HBV-infected patients (32 chronic hepatitis B infection patients, 34 healthy carriers, 30 spontaneously recovered cases) and 31 healthy controls were enrolled. Three biallelic (-819,-592,-1082) regions in the IL-10 gene promoter were sequenced for all patients. RESULTS: Genotypes and haplotypes of IL-10 gene promoter region at position -1082, -819 and -592 were not significantly different among controls, HBV recovered cases, carriers and chronic HBV patients. Nevertheless, A/A genotype at position -592 and T/T genotype at position -819 were more frequently seen in the HBV clearance group, while frequency of G/G genotype at position -1082 was more prevalent in the persistence group. GCC/GCC and GCC/ACC haplotypes were significantly observed in anti-HBe positive individuals. CONCLUSIONS: Our findings showed that IL-10 promoter polymorphisms were not correlated with HBV infection prognosis. Nevertheless, individuals carrying high and intermediate producer of IL-10 haplotypes had a better ability to develop anti-HBe than low producer carriers. Kowsar 2013-05-19 /pmc/articles/PMC3734898/ /pubmed/23922563 http://dx.doi.org/10.5812/hepatmon.8803 Text en Copyright © 2013, Kowsar Corp. http://creativecommons.org/licenses/by/3/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sofian, Masoomeh
Kalantar, Ebrahim
Aghakhani, Arezoo
Hosseini, Soudabeh
Banifazl, Mohammad
Eslamifar, Ali
jourabchi, Ali
Farazi, Ali Asghar
Ramezani, Amitis
No Correlation Between Interleukin-10 Gene Promoter Polymorphisms and Hepatitis B Virus Infection Outcome
title No Correlation Between Interleukin-10 Gene Promoter Polymorphisms and Hepatitis B Virus Infection Outcome
title_full No Correlation Between Interleukin-10 Gene Promoter Polymorphisms and Hepatitis B Virus Infection Outcome
title_fullStr No Correlation Between Interleukin-10 Gene Promoter Polymorphisms and Hepatitis B Virus Infection Outcome
title_full_unstemmed No Correlation Between Interleukin-10 Gene Promoter Polymorphisms and Hepatitis B Virus Infection Outcome
title_short No Correlation Between Interleukin-10 Gene Promoter Polymorphisms and Hepatitis B Virus Infection Outcome
title_sort no correlation between interleukin-10 gene promoter polymorphisms and hepatitis b virus infection outcome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734898/
https://www.ncbi.nlm.nih.gov/pubmed/23922563
http://dx.doi.org/10.5812/hepatmon.8803
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